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The aim of the study is to determine if the relationship between a history of childhood maltreatment and suicide risk is related to changes in the expression and epigenetic modification of specific microRNAs, giving a molecular signature of suicide risk in people with CM. Aim 2 is to determine if an acute experimental stressor, the Trier Social Stress Test, influences the expression of these miRNAs in suicidal patients with and without CM. Aim 3 will investigate potential ways by which altered miRNAs may influence CM-associated suicidal behaviours.
Source link: https://clinicaltrials.gov/ct2/show/NCT04923685
Patients with epilepsy and their physicians also have a big problem with Sudden and unexpected death in epilepsy. Up to 20% of patients with onset drug resistant epilepsy will die of a SUDEP by the age of 45, according to a new survey. Patients with seizure-related respiratory dysfunction are classified as such as occurrence of ictal/peri-ictal pulse oxymetry 90%, as described by the presence of ictal/peri-ictal pulse oxymetry 90 percent. The primary aim of the study is to determine the diagnostic value of a series of circulating microRNAs pre-selected because of their participation in the regulation of molecular pathways involved in the respiratory control to identify patients with seizure-related respiratory dysfunction patients with seizure physiometry-related respiratory dysfunction. Patients with drug-resistant focal epilepsy patients undergoing long-term video-EEG monitoring will be compared to those without seizure-related respiratory dysfunction in a population of patients with long-term video-EEG monitoring.
Source link: https://clinicaltrials.gov/ct2/show/NCT03419000
The aim of the report will investigate the effect of two dietary changes on the regulation of plasma exosome microRNA expression in patients with insulin resistance. Planned Participants will be invited through ADs and the study will consist of three visits Planned Participants. PROGRAM STUDY PROGRAM If they consent, the participant will be required to sign the consent form. Participants will be divided into two intervention groups once the insulin resistance patients are identified. Participants will be encouraged not to change their physical activity, and the physical fitness questionnaire will be administered. After a 12-hour fast to determine the area under the insulin and glucose curve and analysis of insulin and glycemic indices, a glucose tolerance test will be carried out for 2 hours. As a confounding factor for concurrent infection, a blood sample will be taken to determine plasma exosome microRNA expression and C-reactive protein. By blocking randomization, the patient will be randomized and randomized. After a 12-hour fast to determine the area under the insulin and glucose curve and measurement of insulinemic and glycemic indices, a two-hour glucose tolerance test will be carried out for two hours. A blood sample will be collected to determine plasma exosome microRNA expression and C-reactive protein as a confounding factor in concurrent infection.
Source link: https://clinicaltrials.gov/ct2/show/NCT05318898
We suspect that allergen exposure and epithelial cell mRNA/miRNA production rises airway smooth muscle contraction and epithelial cell mRNA/miRNA production as a result of locally increased T-cell-derived cytokine production in the area. Participants at Visit 2, participants will be bronchoscopy with segmental allergen administration of either cat or dust Mite standardized allergen extract. Sample investigation will include testing miRNA and mRNA expression in epithelial brushings; analysis of cell surface markers in BAL cells and blood cells; and the collection of endobronchial biopsies for immunostaining of immune cells localization, immunoblotting of smooth cell protein phosphorylation; and smooth muscle cell subculture.
Source link: https://clinicaltrials.gov/ct2/show/NCT02230189
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