Advanced searches left 3/3

Micelles Solubilization - Crossref

Summarized by Plex Scholar
Last Updated: 02 November 2021

* If you want to update the article please login/register

Improvement of Imiquimod Solubilization and Skin Retention via TPGS Micelles: Exploiting the Co-Solubilizing Effect of Oleic Acid

Imiquimod is an immunostimulant drug accepted for the topical treatment of actinic keratosis, exterior genital-perianal excrescences along with shallow basic cell carcinoma that is utilized off-label for the treatment of various kinds of skin cancers cells, including some malignant melanocytic spreadings such as lentigo maligna, irregular mole and other in situ melanoma-related diseases. Imiquimod skin shipment has proven to be a genuine difficulty as a result of its really reduced water-solubility and minimized skin infiltration capability. The formulas were characterized in regards to fragment size, zeta possibility and security with time and micelles performance on the skin was examined through the quantification of imiquimod retention in the skin layers and the visualization of a micelle-loaded fluorescent color by two-photon microscopy. The micellar formula based on TPGS and oleic acid was identified as one of the most interesting in regards to both medication solubility and micellar security.

Source link: https://doi.org/10.3390/pharmaceutics13091476

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions