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Imiquimod is an immunostimulant drug accepted for the topical treatment of actinic keratosis, exterior genital-perianal excrescences along with shallow basic cell carcinoma that is utilized off-label for the treatment of various kinds of skin cancers cells, including some malignant melanocytic spreadings such as lentigo maligna, irregular mole and other in situ melanoma-related diseases. Imiquimod skin shipment has proven to be a genuine difficulty as a result of its really reduced water-solubility and minimized skin infiltration capability. The formulas were characterized in regards to fragment size, zeta possibility and security with time and micelles performance on the skin was examined through the quantification of imiquimod retention in the skin layers and the visualization of a micelle-loaded fluorescent color by two-photon microscopy. The micellar formula based on TPGS and oleic acid was identified as one of the most interesting in regards to both medication solubility and micellar security.
Source link: https://doi.org/10.3390/pharmaceutics13091476
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