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Micelles Delivery - Europe PMC

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Last Updated: 02 May 2022

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Targeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment.

Lung cancer is the leading cause of cancer deaths worldwide, and its treatment remains a challenge in clinic, particularly for non-small cell lung cancer. Biotin conjugation significantly enhanced the carrier's internalization by 1. 2-fold relative to that of non-targeted mixed micelles, according to Cellular uptake results. Que-MMICs demonstrated superior cytotoxicity over Que-MICs and free Que to A549 cells, which effectively caused apoptosis and stopped cell cycle in vitro experiments, according to In vitro results. In addition, Que-MMICs demonstrated good tumor targeting capability and antitumor effectiveness, perhaps due to the combination of increased permeability and retention as well as a robust targeting function.

Source link: https://europepmc.org/article/MED/35343862


pH-responsive and CD44-targeting polymer micelles based on CD44p-conjugated amphiphilic block copolymer PEG- b -HES- b -PLA for delivery of emodin to breast cancer cells.

Emodin is a natural anthraquino with pharmacological involvement in anti-tumor effects. Nanotechnology-based drug delivery systems have demonstrated excellent success for cancer chemotherapy. The constructed polymeric micelles Emo@CD44p-PM have an average size of 154. 5 0. 9 nm as measured by DLS and TEM. The enhanced cellular internalization of Emo@CD44p-PM due to increased exposure of CD44p enhances Emo@CD44p-PM, which in turn increases Emo@CD44p-PM, which in turn improves the cellular internalization of Emo@CD44p-PM efficiently. In addition, the in vitro findings showed that Emo@CD44p-PM has good biocompatibility and anti-tumor properties. Thus, the polymeric micelles Emo@CD44p-PM, which provide a promising delivery program of targeted therapy for breast cancer.

Source link: https://europepmc.org/article/MED/35313287


Preparation of hyaluronic acid-coated polymeric micelles for nasal vaccine delivery.

As nanoparticulate vaccine delivery systems to produce an effective nasal vaccine, Hyaluronic acid-coated biodegradable polymeric micelles were developed as nanoparticulate vaccine delivery devices. We previously reported HA-coated micelles as a result of the formation of a polyion complex of poly-b-polylactide micelles and HA. Under diluted blood pressure conditions, the HA-coated micelles showed specific accumulation in HA receptor-expressing cells as well as high colloidal stability. In mouse bone marrow-derived dendritic cells, HA-coated micelles produced OVA and CpG-DNA, resulting in the upregulation of mRNA encoding IFN- and IL-4 in BMDCs. In the nasal wash, HA-coated micelles produced more IgG in the blood and OVA-specific IgG in the blood and OVA-specific IgG in the blood and OVA-specific IgG in the blood and OVA-specific IgG than control micelles.

Source link: https://europepmc.org/article/MED/35133358


Tumor Tropic Delivery of Hyaluronic Acid-Poly (D,L-lactide-co-glycolide) Polymeric Micelles Using Mesenchymal Stem Cells for Glioma Therapy.

Solid tumor therapy requires Tumor penetration and the accumulation of nanomedicines. CD44 overexpressed on the surface of both MSCs and tumor cells, not only enhanced PTX/HA-PLGA micelle loading in MSCs, but also promoted MSC cell exchange between MSCs and adjacent cancer cells, according to the study. MSC-micelles were able to migrate from normal brain parenchyma to contralateral tumors, leading to the eradication of glioma.

Source link: https://europepmc.org/article/MED/35458619


Poly(ε-Caprolactone)-Methoxypolyethylene Glycol (PCL-MPEG)-Based Micelles for Drug-Delivery: The Effect of PCL Chain Length on Blood Components, Phagocytosis, and Biodistribution.

Background The primary issue with polymeric micelles as drug delivery methods is that the actual delivery rate is not as high as expected, which is closely linked to the interactions with the diverse biological environments such as blood components, phagocytosis, and biodistribution. Herein, we should begin to comprehend these questions about the clinically relevant micelles made of methoxypolyethylene glycol with identical chain lengths and tunable chain lengths, wherein doxorubicin was encapsulated as a model drug. Both in vitro and in vivo, the effects of PCL chain length on the blood components, phagocytosis, and biodistribution were assayed in vitro and in vivo. The micelles have no effect on red blood cells, blood coagulation, and platelet activation. The micelles were in the order of PCL 40 -MPEG > PCL 20 -MPEG >> PCL 20 -MPEG Which was dependent on the PCL chain lengths.

Source link: https://europepmc.org/article/MED/35411141

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

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* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions