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Micelles Delivery - Crossref

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Last Updated: 02 May 2022

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pH-responsive polymer micelles for methotrexate delivery at tumor microenvironments

Abstract Methotrexate anticancer drug was successfully loaded and released in a controlled manner from polymer micelles made of a diblock copolymer of poly-b polymer polypropy. MCT/mPEG-PCL micelles' cytotoxic effect on MCF-7 breast cancer cells was determined by an MTT assay. MCF-7 cells were IC 50 of MICelles at 30 g mL 1. The results indicated that MTX/mPEG-PCL could be a promising drug delivery device for cancer therapy.

Source link: https://doi.org/10.1515/epoly-2020-0064


pH-responsive and CD44-targeting polymer micelles based on CD44p-conjugated amphiphilic block copolymer PEG-b-HES-b-PLA for delivery of emodin to breast cancer cells

Nanotechnology-based drug delivery systems have demonstrated a promising role in cancer chemotherapy. The assembled polymeric micelles Emo@CD44p-PM have an average size of 154. 5 0. 9 nm as characterized by DLS and TEM. The Emo@CD44p-PM also has a high embo-loading capacity, good thermal stability, and pH responsiveness, according to the Emo@CD44p-PM. The increased cellular internalization of Emo@CD44p-PM as a result of increased exposure to CD44p improves the cellular internalization of Emo@CD44p-PM efficiently, according to a new investigation by intracellular uptake. In addition, the in vitro findings showed good biocompatibility and anti-tumor results for Emo@CD44p-PM, as well as anti-tumor benefits. Therefore, the polymeric micelles Emo@CD44p-PM are a promising delivery scheme for breast cancer target therapy.

Source link: https://doi.org/10.1088/1361-6528/ac5f9a


Tumor Tropic Delivery of Hyaluronic Acid-Poly (D,L-lactide-co-glycolide) Polymeric Micelles Using Mesenchymal Stem Cells for Glioma Therapy

Solid tumor therapy is a difficult problem. Tumor penetration and the accumulation of nanomedicines are two of the key issues in solid tumor therapy. CD44 overexpressed on the surface of both MSCs and tumor cells, not only increased PTX/HA-PLGA micelle loading in MSCs, but also promoted MSC-to-teach cell transfer between MSCs and nearby cancer cells, according to the study. MSC-micelles were able to infiltrate from normal brain parenchyma to contralateral tumors, leading to the eradication of glioma. The survival of orthotopic glioma-bearing rats was greatly extended.

Source link: https://doi.org/10.3390/molecules27082419


Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery

The purpose of the present study is to produce novel functional PIC micelles bearing cell attacking ligands on the surface and to determine the possibility of a hydrophobic drug encapsulation. Copolymers spontaneously co-assembled in water into nanosized PIC micelles comprising a core of a polyelectrolyte complex containing poly and poly, as well as a biocompatible mixed shell of disaccharide-modified poly and poly. PIC micelles' drug loading capacity, in vitro drug release profiles, and antioxidant activity were investigated, as well as antioxidant activity. PIC micelles can be used as carriers of hydrophobic substances, thus expanding their potential use in nanomedicine.

Source link: https://doi.org/10.3390/molecules27072178

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* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions