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Mice tumorigenesis - U.S. Department of Veterans Affairs

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Last Updated: 25 October 2021

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Protective Effects of Dietary Grape on UVB-Mediated Cutaneous Damages and Skin Tumorigenesis in SKH-1 Mice.

Non-melanoma skin cancers are one of the most identified cancers cells in the United States and happen extra regularly in men. We previously demonstrated chemoprotective effects of nutritional grape powder versus UVB-mediated skin tumorigenesis in women SKH-1 mice. To broaden on this, right here, we established the results of GP in a short-term UVB exposure procedure in male and women SKH-1 mice, as well as checked out any sex-related differences in UVB carcinogenesis through male SKH-1 mice.

Source link: https://doi.org/10.3390/cancers12071751


Conditional deletion of β-catenin in mammary epithelial cells of Ron receptor, Mst1r, overexpressing mice alters mammary tumorigenesis.

The Ron receptor tyrosine kinase is overexpressed in around 50% of human breast cancers. Transgenic mice overexpressing Ron in the mammary epithelium [mouse mammary growth infection driven -Ron revealing mice] create mammary growths that exhibit up-regulation of β-catenin and β-catenin target genetics. β-Catenin has been shown to be a conciliator of mammary tumorigenesis in different breast cancer designs, consisting of downstream of Ron. To identify the importance of β-catenin in the context of Ron overexpression, we conditionally deleted β-catenin in mammary epithelial cells of MMTV-Ron mice. β-Catenin loss in this design was also connected with reduced expression of cyclin D1.

Source link: https://doi.org/10.1210/en.2011-1543

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions