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Mice Gut Dysbiosis - Europe PMC

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Last Updated: 08 May 2022

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Oral administration of Euglena gracilis paramylon ameliorates chemotherapy-induced leukocytopenia and gut dysbiosis in mice.

Eugna gracilis is a food supplement that is high in beta-glucans, which are stored in the form of granules called paramylon. We established whether EUG improved chemotherapy-induced leukocytopenia and dysbiosis. Prior to gemcitabine therapy, Mice were orally administered EUG. Following four gemcitabine treatments, a more rapid lymphocyte recovery rate was observed. In the spleens of the gemcitabine and EUG/gemcitabine groups, no difference was observed in the percentage of T, B, or myeloid cells or the expression of Dectin-1. This research found that EUG-derived beta-glucans may act as both a biological response regulator and prebiotics for reducing chemotherapy-induced adverse effects.

Source link: https://europepmc.org/article/MED/35490767


Gut Microbiota Dysbiosis and Altered Bile Acid Catabolism Lead to Metabolic Disorder in Psoriasis Mice.

We found that the dysbiotic gut microbiota of 6-month-old psoriasis-like model mice exacerbated psoriasis disease and triggered metabolic abnormality when transplanted into 2-month-old mice in this research. The Parabacteroides distasonis decreases with age in K14-VEGF mice, according to P. distasonis, which has also decreased in the transferred mice, according to By 16S RNA gene sequencing. As a result, we discovered that aberrant bile acid metabolism in K14-VEGF-A-transgenic mice could contribute to metabolic disorder in psoriasis mice, raising the possibility of preventing and treating the metabolic disorder in psoriasis mice by attacking gut microbial metabolites.

Source link: https://europepmc.org/article/MED/35495722

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* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions