Mice brain mitochondrial function - U.S. Department of Veterans Affairs

Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice.

We reveal that reduced respiration and raised generation of hydrogen peroxide in isolated Surf1 KO brain mitochondria are related to raised brain sugar metabolic process, analytical blood circulation, and lactate levels, and with improved memory in Surf1 KO mice. These metabolic and practical adjustments in Surf1 KO minds were gone along with by higher degrees of hypoxia-inducible factor 1 alpha, and by boosts in the activated form of cyclic AMP response element-binding element, which is essential to memory development.

Source link: https://doi.org/10.1038/jcbfm.2013.116

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