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Mice Skin Wound Healing - Wiley Online Library

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Last Updated: 09 May 2022

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Lentivirus‐mediated subcutaneous JAM‐A modification promotes skin wound healing in a mouse model by strengthening the secretory function and proliferation of fibroblasts

A better understanding of wound healing's molecular mechanism could lead to novel therapeutic targets. A previous research found that junctional adhesion molecule A modified mesenchymal stem cells promoted wound healing. However, whether direct JAMA enhancement in the skin wound edge area expedites the wound repair process is not certain. We determined that JAM-A changes at the skin wound edge accelerated the wound healing process. To determine the cell proliferation of mouse primary fibroblasts, primary fibroblasts were measured by CCK-8 assays and immunofluorescence for Ki67. At Day 7, the JAMA>overexpressing group had a smaller residual wound size than the control group. In the JAM's overexpressing group on Day 21, Thicker epidermal layers and several hair follicle shaped structures were discovered. In the JAM-A-modified group in vivo and in vitro, elevated amounts of bFGF and EGF were discovered in vivo and in vitro. Increased amounts of bFGF and EGF growth factors may be a contributing factor.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/cbin.11808

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions