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Mice Skin Wound - Wiley Online Library

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Last Updated: 09 May 2022

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Lentivirus‐mediated subcutaneous JAM‐A modification promotes skin wound healing in a mouse model by strengthening the secretory function and proliferation of fibroblasts

A better understanding of wound healing's molecular mechanisms may help with new therapeutic goals. A new analysis revealed that junctional adhesion molecule A modified mesenchymal stem cells enhanced wound healing. However, whether direct JAMA reinforcement in the skin wound edge area expedites the wound repair process is not certain. We found out whether JAMA's skin wound patching procedure was expedient. We developed JAM-A modification mouse wound models and mouse primary fibroblast cell models. To determine mouse primary fibroblast cell proliferation, mouse primary fibroblasts were used in CCK8 experiments and immunofluorescence for Ki67. At Day 7, the JAM-Aroverexpressing group had a smaller residual wound size than the control group. In the JAM-Aoverexpressing group on Day 21, Thicker epidermal layers and some hair folliclelike structures were discovered. In the JAM-Aftified group in vivo and in vitro, elevated amounts of bFGF and EGF were discovered.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/cbin.11808

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