Mice Skeletal Muscle Atrophy - U.S. Department of Veterans Affairs

CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice.

To explore the relative functions of skeletal muscle and motor nerve cells in this procedure, we utilized a Cre-Lox targeted technique to establish a skeletal muscle-specific Sod1-knockout mouse to figure out whether muscle-specific CuZnSOD removal suffices to create muscle atrophy. Remarkably, mKO mice keep muscle masses at or above those of wild-type control mice up to 18 mo of age. Our information show that lack of CuZnSOD limited to skeletal muscle does not lead to muscle atrophy yet does cause muscle weak point in adult mice and recommend loss of CuZnSOD might potentiate muscle regenerative paths.

Source link: https://doi.org/10.1096/fj.13-228130

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