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Mice Liver Cells - BioProject

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Last Updated: 09 February 2022

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Single cell RNA-seq of liver cells from B6J mice fed a chow or a high-fat-and-high-sucrose diet

To find out if CB-1 signaling plays a role in the development of NAFLD or liver fibrosis, we created mice that were lacking CB-1 receptors in hepatocytes or stellate cells. CB-1 receptors in hepatocytes did not influence the development of NAFLD in mice fed a high sucrose high fat diet or high fat diet, but not in mice fed a high sucrose high fat diet or high fat diet. In addition, deletion of CB-1 gene expression in stellate cells specifically did not prevent the formation of NAFLD in mice fed the HFD, nor did it shield mice from carbon tetrachloride-induced fibrosis. Here we performed single cell RNA-sequencing of livers from wild-type mice fed chow or a HSD for 17 weeks and determined CB-1 expression in livers from a small population of cells in livers with elevated CB-1 levels either before and/or after HSD feeding. To find out if a small population of cells in liver express CB-1 at elevated rates before and/or after HSD feeding, here we did. To determine whether a small population of livers.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/756014


Smart-seq for HBs-specific CD8+ T cells sorted from C57BL/6 mice and C57BL/6-Tg (HBV Alb-1) Bri44 HBV transgenic mice liver

Previous studies have paid more attention to hepatitis B e antigen intrauterine exposure, but the effect of solely hepatitis B surface antigen exposure on offspring's immune response against hepatitis B virus is still unclear.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/682742

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions