Mice Glucose Intolerance - U.S. Department of Veterans Affairs

Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice.

In this research study, we checked whether overexpression of Trx1 in mice [Tg] might secure from glucose metabolic process disorder triggered by high fat diet plan feeding. Body weight and fat mass gains with high fat feeding were similar in Tg and wild-type mice; however, high fat diet regimen caused glucose intolerance was lowered in Tg mice about wild-type mice. In enhancement, expression of the pro-inflammatory cytokine TNF-α was decreased in fat of Tg mice contrasted to wild-type mice.

Source link: https://doi.org/10.3402/pba.v2i0.17101

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