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Mice Glucose Homeostasis - U.S. Department of Veterans Affairs

Summarized by Plex Scholar
Last Updated: 16 February 2022

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Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice.

Mice fed an HI diet exhibited elevated AMP-activated protein kinase production as well as impaired insulin signaling in skeletal muscle and liver. In mice fed an HI diet, glucose uptake was increased in accordance with the increase in AMPK activity. With the expression of muscle specific dominant-negative AMPK, improved glucose tolerance induced by HI feeding in transgenic mice were reversed. AMPK was activated by increasing deacetylase and decreasing LKB1 acetylation, which in turn increased phosphorylation of LKB1 and AMPK. In summary, a diet high in iron improves glucose tolerance by inactivating AMPK by mechanisms that include deacetylation.

Source link: https://doi.org/10.1096/fj.12-216929

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions