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Mice Glucose Homeostasis - Crossref

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Last Updated: 16 May 2022

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Abstract P142: B Cell Activating Factor Neutralization In High-Fat Diet-Induced Obese Mice Retains Adipose Tissue B Cells And Exacerbates Glucose Homeostasis

Adults with type 2 diabetes have a two-fold greater risk of cardiovascular disease. Male C57BL/6J mice fed on a high-fat diet for 12 weeks were divided into two groups based on their glucose intolerance determination by a glucose tolerance test. Two weeks after the first anti-BAFF antibody injection, BAFF neutralization was demonstrated by depletion of B2 B cells in the blood, two weeks after the first anti-BAFF antibody injection. BAFF neutralization depleted mature B2 B cells in the spleen and blood, according to extensive cell phenotyping using flow cytometry, but not affect the CD4+ T cells and CD8+ T cells. B2 cells were retained in the VAT of anti-BAFF antibody-treated mice, but the number of CD4+ T cells and dead adipocytes was higher, which was unexpectedly. Our results, in turn, highlight the need for further research into the use of anti-BAFF biologics for the treatment of diabetic systemic lupus erythematosus patients.

Source link: https://doi.org/10.1161/atvb.41.suppl_1.p142


Styrylpyrones from Phellinus linteus Mycelia Alleviate Non-Alcoholic Fatty Liver by Modulating Lipid and Glucose Metabolic Homeostasis in High-Fat and High-Fructose Diet-Fed Mice

Phellinus linteus, an edible and medicinal mushroom containing a variety of styrylpyrone-type polyphenols, has been shown to have a broad variety of bioactivities. The submerged liquid culture of fermentor culture in a 1600-L working volume of fermentor was used for the large-scale production of PL mycelia. It is also unknown if PL mycelia extract is safe against nonalcoholic fatty liver disease. The dietary supplementation of ethyl acetate fraction from PL mycelia for four weeks prevented an increase in body weight, hepatic lipid accumulation, and fasting glucose levels in the high fat/high fructose diet-induced NAFLD C57BL/6 mice study.

Source link: https://doi.org/10.3390/antiox11050898


The bile acid TUDCA improves glucose homeostasis through increase of insulin levels in mice with Alzheimer's disease

According to studies, people with T2DM are at a higher risk of AD. Insul resistance and downstream abnormalities in the insulin signaling pathway are both present in the AD brain and contribute to cognitive dysfunction.

Source link: https://doi.org/10.20396/revpibic262018908


Adaptive Changes in Glucose Homeostasis and Islet Function During Pregnancy: A Targeted Metabolomics Study in Mice

However, a complete analysis of the maternal islet metabolome in relation to islet function and the ambient circulating metabolome during pregnancy has yet to be established. Throughout the gestational period, fasting glucose and insulin were found to be significantly lower in pregnant mice relative to non-pregnant controls. In addition, pregnant mice had higher glucose excursions and increased insulin response to an oral glucose tolerance assessment. When comparing the plasma metabolomes of pregnant and non-pregnant mice, phospholipid and fatty acid metabolism pathways were discovered throughout pregnancy, but later increased in late pregnancy. This research provides insight into metabolic changes in glucose homeostasis and islet function seen during pregnancy, providing a molecular basis for further investigating maternal metabolism control to minimize pregnancy-related diabetes, especially gestational diabetes.

Source link: https://doi.org/10.3389/fendo.2022.852149

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions