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Mice Colon Tumorigenesis - Europe PMC

Summarized by Plex Scholar
Last Updated: 25 January 2022

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Elevated MMP10/13 mediated barrier disruption and NF-κB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice.

We made knockout mice for individual miR-148/152 family members and the entire MiR-148/152 family for the first time. We conduct the first comprehensive review of miR-148/152 families, revealing that deficiency of any member of miR-148/152 family causes colitis and CAC. MiR-148/152 family members' deficiency in mice has elevated MMP10 and MMP13 in colitis and CAC by disrupting intestinal barrier function and initiating NF-B signaling, triggering NF-B signaling, suggesting a potential therapeutic intervention for colitis and CAC.

Source link: https://europepmc.org/article/MED/34979166

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions