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We made knockout mice for individual miR-148/152 family members and the entire MiR-148/152 family for the first time. We conduct the first comprehensive review of miR-148/152 families, revealing that deficiency of any member of miR-148/152 family causes colitis and CAC. MiR-148/152 family members' deficiency in mice has elevated MMP10 and MMP13 in colitis and CAC by disrupting intestinal barrier function and initiating NF-B signaling, triggering NF-B signaling, suggesting a potential therapeutic intervention for colitis and CAC.
Source link: https://europepmc.org/article/MED/34979166
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