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Metronidazole - Crossref

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Last Updated: 23 April 2022

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Fabrication and In Vitro/In Vivo Appraisal of Metronidazole Intra-Gastric Buoyant Sustained-Release Tablets in Healthy Volunteers

Helicobacter pylori is believed to be the most common cause of peptic and duodenal ulcers. According to the manufacturer, we set out to develop and analyze sustained release floating tablets for metronidazole to prolong the gastric residence period and control the release rate of metronidazole. Floating tablets containing cellulose derivatives and Avicel were made using direct compression. According to the Hichi model, the rate of metronidazole release from the floating tablets was less than that from conventional tablets, indicating continued drug delivery. After a single oral dose of 150 mg metronidazole as floating tablets, a In vivo study in healthy volunteers revealed significantly improved bioavailability; increased Tmax, AUC, and MRT; and even lower absorption rate constant. In addition, the significant rise in MRT indicated an in vivo sustained drug release.

Source link: https://doi.org/10.3390/pharmaceutics14040863


Metronidazole-Induced Hepatitis in a Teenager With Xeroderma Pigmentosum and Trichothiodystrophy Overlap

Cells from the patient's cultured skin fibroblasts demonstrated cellular tolerance to death by metronidazole compared to cells from a variety of other donors. Patients with Cockayne syndrome, another NER disorder, are at a high risk of metronidazole-induced hepatiotoxicity, according to studies of other NER disorders, but this has not been reported in patients with other NER disorders. We should be cautious with metronidazole's use in the treatment of people with xeroderma pigmentosum and trichothiodystrophy phenotypes.

Source link: https://doi.org/10.1542/peds.2021-050360


Assay of Metronidazole from Different Manufacturing Sources in Iraqi Markets

The experimental research included measuring the exact amount of Metronidazole in samples, which are different pharmaceutical companies in Iraq's pharmaceutical market, to determine the presence of drug in dosage form in these samples.

Source link: https://doi.org/10.32947/ajps.v5i1.373


Floating Drug Delivery Systems Using Metronidazole as a Model Drug Part I: By Effervescent Method

Any types of medications are available in a variety of dosage forms, and gastric retentive dosage forms are especially effective. One of the methods used to obtain extended gastric residence time is using floating dosage forms. Forming of a effervescent single-unit floating drug delivery system for MDZ involves both local and systemic drug therapy for eradication of Helicobacter pylori, a gram-negative bacterium that is associated with gastric inflammation, peptic ulcer, and gastric cancer. e. g.

Source link: https://doi.org/10.32947/ajps.v13i2.199


Efficacy of Intra Alveolar Placement of Chlorhexidine 0.2% with Metronidazole 10mg Gel for Prevention of Dry Socket

On day 1 and day 5 post-operatively, In group A After the extraction of tooth Chlorhexidine 0. 2% with Metronidazole 10mg, tooth socket was irrigated with normal saline and patients were recalled for assessment of pain by wong bakers scale, the tooth socket was irrigated with wing bakers scale. Results: The average age of group A patients was 28. 38+4. 52 years, with an average age of group B patients of 37. 04+7. 32 years. Females were found in majority in both groups at 66. 6 percent in group A and 53. 3 percent in group B, with 63. 6% in group A and 56. 3 percent in group B. Compared to group A, p-values were significantly lower in group A from first to fifth operative days, although group B's average was significantly lower in group A. In comparison to group B, which was 88. 6%, the frequency of dry socket was significantly lower in group A at 47. 7%.

Source link: https://doi.org/10.53350/pjmhs22162728


Reduced transcription of the ferredoxin gene in metronidazole-resistant Trichomonas vaginalis.

Metronidazole [1--2-methyl-5-nitroimidazole] is used to treat infections caused by Trichomonas vaginalis, a sexually transmitted human parasite. The role of ferredoxin in metronidazole resistance has been investigated by researchers. In the resistant strains relative to a sensitive strain, immunoblot review of drug-resistant and -sensitive T. vaginalis strains shows that intracellular levels of ferredoxin are consistently reduced in the resistant strains relative to a delicate strain. Ferredoxin mRNA levels are reduced 5 to 5 percent in resistant strains, according to a Northern blot study. We find that ferredoxin gene expression is reduced by 40% in resistant strains by using nuclear run-on assays. In a resistant strain, two point mutations in the region 5' of the ferredoxin gene among drug-sensitive and -resistant strains is found, with -178 and -239 nucleotides relative to the start of transcription. These results show a strong correlation between drug resistance and changes in ferredoxin gene expression regulation. Ferredoxin levels in intracellular levels have decreased as a result of a gene transcription decrease.

Source link: https://doi.org/10.1073/pnas.89.10.4402


Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques

Hypothesized to decrease therapy for active tuberculosis and prevent latent infection reactivation in low-oxygen microenvironments, such as caseous granulomas. On low-dose M. tuberculosis infection, equal amounts of cynomolosis macaques develop active disease or latent infection, and that latently infected animals are reactivated on TNF neutralization. We now demonstrate that with 6 mo of isoniazid, chemoprophylaxis of latently infected cynomolgus macaques has effectively stopped anti-TNF antibody-induced reactivation. We also found that during active TB, hypoxic lesions also occur. We also found that MTZ addition to INH/RIF treated animals with active TB within 2 mo. Our results in the nonhuman primate model of active and latent TB supports reveal bacteria in hypoxic environments for preventing latent infection reactivation and potentially shortening the duration of therapy in active TB.

Source link: https://doi.org/10.1073/pnas.1121497109


Serum Level Profile and Pharmacokinetic Parameters of Single Oral Dose of Metronidazole in Type II Diabetic Patients

People with diabetes can have a variety of pathophysiological disorders that may influence the drug's pharmacokinetic properties. Following a 10-hour fasting, a single oral dose of metronidazole 500 mg was administered orally to all participants on day 1. Blood samples were collected at regular intervals over the course of 48 hours, and serum metronidazole concentrations were determined by a high-performance liquid chromatography method for determining metronidazole's pharmacokinetics. In diabetic patients, the maximum serum concentration and Kelim had significantly reduced, according to the study in healthy individuals.

Source link: https://doi.org/10.31351/vol20iss1pp14-18


A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial

The aim of this review was to determine the effectiveness of various oral antibiotics for the prevention of dry socket and pneumonia in adults after dental extraction in LA. Thirteen patients were in the postoperative co-amoxiclav group, 15 in the preoperative co-amoxiclav plus postoperative metronidazole group, and fifteen in the preoperative co-amoxiclav plus postoperative amoxicillin group. Compared to the co-amoxiclav group at 5 days post-operation, there was no significant decrease in the number of patients with acute alveolar osteitis or infection for co-amoxiclav plus metronidazole and co-amoxiclav plus amoxicillin groups. In addition, mean pain scores at 5 days post-operative were down drastically, relative to the pain levels immediately after surgery. Conclusions: After surgical extractions, administration of a single preoperative dose of amoxicillin or metronidazole, as well as conventional therapy with postoperative co-amoxilcalv was more cost effective than postoperative co-amoxiclaves in lowering the risk of both alveolar osteitis and infection after surgical extractions.

Source link: https://doi.org/10.3390/ijerph19074178


Local delivery of metronidazole loaded N-trimethyl quaternary ammonium chitosan nanoparticles for periodontitis treatment

Background: The underlying mechanism of chitosan's antibacterial activity was found in various ways, according to the amine group's conversion of the chitosan's amine group in a quaternary ammonium compound, but chitosan's antibacterial activity was enhanced as a result of an increase in the solubility of the amine group in the acidic environment. Objectives: This research was designed to develop and standardize metronidazole-loaded N-trimethyl quaternary ammonium chitosan nanoparticles for the treatment of periodontitis. The optimized batches were found that the formulation could be stored even after 6 months, with 99% 98. 97 7. 7% of the drug being released within 24 hours in vitro to get a sustained release drug. Result: N-trimethyl quaternary ammonium chitosan nanoparticles loaded with metronidazole shows enhanced antibacterial activity against periodontal infections, according to the present study.

Source link: https://doi.org/10.2174/1574885517666220331145439

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions