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Metoprolol - DOAJ

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Last Updated: 23 April 2022

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Interaction of Palmitic Acid with Metoprolol Succinate at the Binding Sites of Bovine Serum Albumin

Methods: By equilibrium dialysis method at 27°C and pH 7. 4, metoprolol succinate's binding to bovine serum albumin was investigated in order to gain insight into the drug's binding chemistry in presence and absence of palmitic acid. Two sets of association constants were proposed: metoprolol succinate binding to bovine serum albumin by a different method: high affinity association constant with low capacity and low affinity association constant with high capacity at pH 7. 4 and 27°C. Palmitic acid displaced metoprolol succinate from its binding site on BSA during simultaneous administration of metoprolol succinate or in absence of ranitidine or diazepam.

Source link: https://doi.org/10.5681/apb.2014.056


Endothelial function is unaffected by changing between carvedilol and metoprolol in patients with heart failure-a randomized study

During treatment with carvedilol, metoprolol tartrate, and metoprolol succinate in patients with HF, we investigated if there were differences in endothelial function, insulin-stimulated endothelial function, 24 hour ambulatory blood pressure, and heart rate. 1. 39 0. 33 before and after treatment; 1. 43 0. 1 before and after treatment; and 2. 42 0. 37 after and after treatment; respectively, 1. 42 0. 33 in the carvedilol group and 2. 43 0. 33 before and after therapy; and 2. 41 0. 33 before and after treatment; and 2. 41 0. 33 after two months of serotonin therapy; 1. 37 0. 33 before and after therapy; 1. 42 0. 32 0. 33 Conclusion In this review, endothelial function remained unchanged when switching the beta blocker therapy from carvedilol to either metoprolol tartrate or metoprolol succinate, where blood pressure and heart rate remained unchanged in patients with mild HF.

Source link: https://doi.org/10.1186/1475-2840-10-91


Antihypertensive efficacy of metoprolol XL/Low dose chlorthalidone (6.25 mg) combination: a randomized, comparative study in Indian patients with mild-to-moderate essential hypertension

With respect to fall in systolic and diastolic blood pressure, the primary aim was to determine the safety of metoprolol XL/chlorthalidone against metoprolol XL/chlorthalidone. Both the step-up therapies showed similar mean decline in SBP and DBP after 4-weeks of administration. However, a substantial number of patients from the chlorthalidone 12. 5 mg/metoprolol XL 50 mg group responded to therapy compared to the HCTZ 12. 5 mg/metoprolol XL 50 mg group. Conclusion Chlorthalidone in combination with metoprolol XL is as safe and well tolerated as a commonly used combination of metoprolol XL/HCTZ, providing an alternative therapeutic option.

Source link: https://doi.org/10.1186/2047-783X-14-7-297


Metoprolol alleviates arginine vasopressin-induced cardiomyocyte hypertrophy by upregulating the AKT1–SERCA2 cascade in H9C2 cells

Abstract Background Arginine vasopressin is elevated in patients with heart failure, and the rise in the AVP concentration in plasma is positively related to disease severity and mortality. Our current research sought to determine the inhibitory effects of Met on AVP-induced cardiomyocyte hypertrophy and the underlying mechanisms. Methods AVP alone or AVP plus Met was added to the wild type or AKT1-overexpressing rat cardiac H9C2 cell line. The pathogenesis of AVP-induced cardiomyocyte hypertrophy was illustrated by AKT1 but not AKT2 in the current study. In addition, AKT1 overexpression enhanced the expression of SERCA2 and reduced the expression of PLN in the H9C2 cells. Moreover, we discovered that Met could attenuate AVP-induced changes in AKT1, SERCA2, and PLN expression, as well as reduced the cytoplasmic calcium content in the H9C2 cells.

Source link: https://doi.org/10.1186/s13578-020-00434-y


Differential Effects of Ivabradine and Metoprolol on Cardiovascular Remodeling and Myocardial Infarction Induced by Isoprenaline in Chronic N-nitro-L-arginine Methyl Ester (L-NAME) Treated Rats

Aim: This research was conducted to investigate the effects of the two bradycardiac agents ivabradine and metoprolol on cardiovascular disease and mortality in the general population and in patients with cardiovascular disease and cardiovascular disease are both elevated. Four groups of male Wistar rats were tested: the 1st group was treated as a normal control, the 2nd group was treated with L-NAME plus ivabradine, and the 3rd group was treated with the same dose of L-NAME plus metoprolol, while the 4th group was treated with the same dose of L-NAME plus metoprolol. Conclusions: These results suggest that ivabradine has a significant protective role against isoprenaline-induced myocardial infarction in chronic L-NAME-treated rats.

Source link: https://doi.org/10.11131/2012/101333


Carvedilol in the treatment of chronic heart failure: Lessons from The Carvedilol Or Metoprolol European Trial

Bio-blockers have been shown to improve heart health in patients with chronic heart disease, according to Atheline Major-Petersen, Buris Christiansen, Christian Torp-Pedersen, Bethesen, Bispebjerg University Hospital, Copenhagen, Denmark. Abstract: Beta-blockers have been shown to promote heart health in patients with chronic heart failure. In placebo-controlled studies, both metoprolol and carvedilol have shown beneficial results. This is the first concrete comparison of metoprolol and carvedilol in patients with persistent heart disease. At this moment, there is unresolved debate over whether carvedilol is a good beta-blocker or whether differences in beta1-blockade explain the results of COMET, key words: beta-blockers, chronic heart failure, carvedilol.

Source link: https://doaj.org/article/a0bad6b2feca46f0bea9a7074b2d543f


Metoprolol rescues endothelial progenitor cell dysfunction in diabetes

However, the effect of -blockers on diabetes's endothelial progenitor cells function is also unknown. Metoprolol improved EPC performance among the five -blockers, and was selected for the in vitro studies in STZ-induced diabetic mice. In diabetic mice, glucose tolerance was drastically reduced, and circulation EPC number was restored, but metoprolol treatment improved EPC migration capabilities and circulation EPC numbers. In addition, metoprolol greatly enhanced eNOS phosphorylation and decreased O2 levels in diabetic mice's EPCs. Metoprolol can accelerate wound healing in diabetic mice and improve endothelial function in diabetic patients, which can be mediated in part by improved EPC function.

Source link: https://doi.org/10.7717/peerj.9306


Metoprolol, N-Acetylcysteine, and Escitalopram Prevents Chronic Unpredictable Mild Stress-Induced Depression by Inhibition of Endoplasmic Reticulum Stress

History: Endoplasmic reticulum stress has been recently found to be triggered in the major depressive disorder. However, whether ERS is a potential therapeutic target for MDD is largely unknown. By transmission electron microscope, Hippocampal nerve cells and capillary ultrastructure were observed, and hippocampal cell apoptosis were detected by flow cytometry, and hippocampal cell apoptosis was detected by flow cytometry. Results: Furthermore, expression of ERS markers glucose-regulated protein 78, C/EBP-homologous protein, and caspase-12 were found by western blot and qRT-PCR. Moreover, CUMS-exposed rats exhibited significant hippocampal cell apoptosis, exhibited impairment in hippocampal nerve cells, and capillary ultrastructure, respectively. ERS proved to be a novel treatment target for depression in these reports.

Source link: https://doi.org/10.3389/fpsyt.2018.00696


A validated high-resolution accurate mass LC-MS assay for quantitative determination of metoprolol and α-hydroxymetoprolol in human serum for application in pharmacokinetics

To determine metoprolol and its metabolite hydroxymetoprolol in human serum, we established a method using an Exact® Orbitrap mass spectrometer as detector and isotope-labelled metoprolol-d7 as the internal benchmark. This validated LC-Orbitrap MS report for metoprolol and hydroxymetoprolol can be used for application in human pharmacokinetics.

Source link: https://doi.org/10.17145/jab.17.008


Effect of Naoxintong Capsules on the Activities of CYP450 and Metabolism of Metoprolol Tartrate in Rats Evaluated by Probe Cocktail and Pharmacokinetic Methods

AUC and AUC of midazolam in NXT coadministration group were significantly reduced as compared to another group, according to the report, although dextromethorphan reported the opposite tendency. In addition, NXT pre-administration can extend metoprolol tartrate metabolism and reduce O-demethylmetoprolol metabolism. In the metabolism of metoprolol tartrate, the results showed that NXT had potential effects in inducing CYP3A4 and inhibiting CYP2D6. Patients who coadministered NXT and metoprolol tartrate may be warned of potential herb-drug interactions in the event of therapeutic failure or early toxicity of traditional drug therapy, according to it.

Source link: https://doi.org/10.1155/2019/5242605

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions