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Methylphosphonic Acid - Crossref

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Last Updated: 23 April 2022

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Determination of methylphosphonic acid and alkyl methylphosphonic acid esters in soils by liquid chromatography-high-resolution mass spectrometry (LC-HRMS)

The detected ions in the fragmentation mass spectra of deprotonated molecules of EMPA, IPMPA, IBMPA, PMPA, MPA, and MPA's PMPA, MPA, and their respective deuterated molecules' deuterated molecules, as well as potential fragmentation formulas are given. To prepare soil samples for analysis, Liquid extraction followed by deionization water and evaporation is used. Sample collection and analysis of soil samples does not exceed 1 hour.

Source link: https://doi.org/10.26896/1028-6861-2022-88-1-i-25-33


Effect of Gold Nanoparticles Size on Detection of Methylphosphonic Acid Hydrolysis Product of Nerve Agent

A common technique to synthete citrate-capped gold nanoparticles is citrate reduction of gold chloride trihydrate. For the detection of methylphosphonic acid using colorimetric incorporated with image processing, smaller particles size of cit-AuNPs results in greater stability and sensitivity for detecting methylphosphonic acid via colorimetric incorporated with image processing with a linear range of 2. 5 to 12. 5 mM and a lower detection limit of 6. 28 mM with a shorter detection period.

Source link: https://doi.org/10.25303/257rjce0121


Friedel–Crafts-type reaction of pyrene with diethyl 1-(isothiocyanato)alkylphosphonates. Efficient synthesis of highly fluorescent diethyl 1-(pyrene-1-carboxamido)alkylphosphonates and 1-(pyrene-1-carboxamido)methylphosphonic acid

In 83–94% yield, the pyrene with diethyl 1-alkylphosphonates promoted by trifluoromethanosulfonic acid gave rise to trifluoromethane-related reaction of pyrene with diethyl 1-alkylphosphonates obtained by trifluoromethanosulfonic acid produced by trifluoromethane afforded diethyl 1-alkylphosphonates. By treating the corresponding diethyl phosphonate with Me 3 Si-Br in methanol, a 87 percent yield was achieved in a 87% success. In comparison to that of a model N pyrene-1-carboxamide, the presence of a phosphonato group resulted in about twofold rise in solution fluorescence quantum yield in comparison to that of a model N -alkyl pyrene-1-carboxamide. The presence of diethyl 1-methylphosphonate was traced to – aggregates in solid-state emission, the presence of which was revealed by single-crystal X-ray diffraction analysis.

Source link: https://doi.org/10.3762/bjoc.11.266


Toxicity of Binary Chemical Munition Destruction Products: Methylphosphonic Acid, Methylphosphinic Acid, 2-Diisopropylaminoethanol, DF Neutralent, and QL Neutralent

This paper explores the toxicity and environmental consequences of neutralents made from the hydrolysis of binary chemical agent precursor chemicals DF and QL. The 48-h LC 50 values for pH-adjusted DF neutral with Daphnia magna and Cyprinodon variegatus were > 2500 mg/L and 1593 mg/L, respectively. Both the acute and post-labor LD50 values in the rats for QL neutral constituents methylphosphinic acid and 2-diisopropylaminoethanol were found to be 940 mg/kg, while the Ames test was negative for both. Both acute oral and dermal toxicity testing results were > 5000 mg/kg, and 48-h LD 50 values for D. magna and C. variegatus were 249 and 2500 mg/L, respectively.

Source link: https://doi.org/10.1080/10915810701707551


A Brief Overview of HPLC–MS Analysis of Alkyl Methylphosphonic Acid Degradation Products of Nerve Agents

Abstract derived from the recent study of degradation products from the classic chemical warfare nerve agents by high-performance liquid chromatography-mass spectrometry has piqued much attention in recent years, due to the possibility of use as a terrorist weapon and the use of chemical weapons in war torn countries in recent years.

Source link: https://doi.org/10.1093/chromsci/bmz034


Synthesis of O-tyrosine Phosphorylated Adducts of Methylphosphonic and Phosphoric Acid Derivatives as Reference Compounds for the Analysis of Biomedical Samples

Organophosphorus chemical agents are listed in the 1st List of Chemicals of the Convention on the Prohibition of the Production, Processing, and Use of Chemical Weapons and Upon their Destruction. Organophosphate toxic agents are well-known tyrosine phosphorylation agents, the presence of which in biomedical samples shows direct exposure to sarin, soman, tabun, and V-series agents. We have devised elaborated protocols for the synthesis and isolation of tyrosine adduct derivatives of methylphosphonic and phosphoric acids used as reference samples. The synthesis program included successive protection of carboxyl and amino groups of tyrosine, its O-phosphorylation by the relevant alkylphosphonates and phosphates, as well as the removal of protective groups with the release of equivalent O-phosphorylated tyrosine adducts. Under atmospheric pressure, the phosphorylated L-tyrosines' protective layer of benzyl and carboxybenzyl was removed by means of catalytic hydrogenation by molecular hydrogenation.

Source link: https://doi.org/10.35825/2587-5728-2019-3-2-103-110


Selective Protection of 1,4,8,11-Tetraazacyclotetradecane (Cyclam) in Position 1,4 with the Phosphonothioyl Group and Synthesis of a Cyclam-1,4-bis(methylphosphonic Acid). Crystal Structures of Several Cyclic Phosphonothioamides

In a modest yield, Cyclam was shielded by PhPCl 2's reaction to produce exclusively five-membered cyclic phenylphosphated diamide 2 in a moderate yield. Compound 2 was isolated as two stable conformers differing in their cyclam ring's mutual position of benzene ring and sulfur atom with respect to the cyclam ring. However, the deprotection of the thiophosphoryl-protected bis with aqueous HCl under non-optimized conditions resulted in a mixture of cyclam derivatives substituted with methylphosphonic acid groups.

Source link: https://doi.org/10.1135/cccc20060337


Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes with H5do3ap (1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic-10-(methylphosphonic Acid)), a Monophosphonate Analogue of H4dota

In solution, successive attachment of protons has resulted in several reorganizations of protonation sites and the neutral zwitterionic species H 5 do3ap has the same solution geometry as in the solid state, where the nitrogen atom binding methylphosphonate and the opposite nitrogen atoms are protonated. The reaction intermediates are the H 5 do3ap complexes' cellular mechanism, as the reaction intermediates are related to that described for H4 dota complexes and the complicated species of mono- or diprotonated ligand on the cyclen ring. The decomplexation of H 5 do3ap complexes by acid-assisted decomplexation of H 5 do3ap complexes is quicker than that of H4 dota. This is owing to the increased phosphonate pendant arm and the ring nitrogen atoms, which aids in proton transfer from the bulk solution to the nitrogen atoms of cyclen ring.

Source link: https://doi.org/10.1135/cccc20051909

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions