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Methylmalonic Acid - PubAg

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Last Updated: 16 October 2021

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Complex oscillations in the Belousov–Zhabotinsky batch reaction with methylmalonic acid and manganese(ii)

The Belousov-- Zhabotinsky oscillating chemical reaction includes the oxidation of a natural substance by the bromate ion in the existence of a metal ion driver such as cerium, ferroin, or manganese. Basic regular oscillations are generally acquired for the BZ response in a set system. We report here that interesting complicated oscillations in the possibility of a Pt electrode have been found in the set BZ response with methylmalonic acid and manganese. Fairly high initial concentrations of NaBrO ₃ and MeMA are required, and the [NaBrO ₃] ₀/ [MeMA] ₀ proportion is the main factor establishing the sort of oscillations obtained.

Source link: https://pubag.nal.usda.gov/catalog/7372341


Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats

Exploration of particular pens that mirror modified hepatic fatty acid oxidation can help to discover an individual's danger of fatty liver, type 2 diabetic issues and cardiovascular condition at a beginning. Lipid and healthy protein metabolic process are totally connected, however our understanding of this crosstalk remains limited. In male Wistar rats, we utilized artificial fatty acid analogues as a device to induce hepatic fatty acid oxidation and mitochondrial biogenesis, to get new insight into the link in between fat oxidation, amino acid metabolism and TCA cycle-related intermediate metabolites in liver and plasma. Rats treated with 3-thia fatty acids had 3-fold higher hepatic, however not adipose and skeletal muscle, expression of the thioesterase 3-hydroxyisobutyryl-CoA hydrolase, which regulates the formation of 3-hydroxyisobutyrate in the valine deterioration pathway. Subsequently, 3-thia fatty acid-stimulated hepatic fat oxidation and ketogenesis was gone along with by lowered plasma 3-HIB and boosted methylmalonic acid concentrations even more downstream in BCAA assimilation.

Source link: https://pubag.nal.usda.gov/catalog/7242821


High protein prescription in methylmalonic and propionic acidemia patients and its negative association with long-term outcome

It is unidentified if nutritional treatment can have an influence on outcome. We performed an across the country retrospective accomplice study and reviewed both longitudinal nutritional treatment and professional course of Dutch MMA and patients. The organization of longitudinal dietary treatment with lasting outcome was evaluated. The mate consisted of 76 patients with an average retrospective follow-up duration of 15 years and a total amount of 1063 client years on a healthy protein limited diet plan. Natural protein prescription went beyond the RDA in 37% of all prescriptions and because of AAM prescription, the overall protein prescription surpassed RDA in 84%. In PA early start patients a higher all-natural protein prescription was related to even more constant AMD. In MMA vitamin B12 less competent patients, both a greater overall healthy protein prescription and AAM protein prescription were linked with even more mitochondrial issues.

Source link: https://pubag.nal.usda.gov/catalog/7220891


Electrochemical sensing of vitamin B12 deficiency marker methylmalonic acid using PdAu-PPy tailored carbon fiber paper electrode

Vitamin B ₁₂ is very vital for human metabolic rate and its deficiency can create anemia and the manufacturing of huge red blood cells. An enhanced focus of methylmalonic acid is found much before the makeover of blood cells, which consequently is an early indicator for severe or moderate Vitamin B ₁₂ deficiency. A simple electrochemical sensor based on Palladium-- Gold was created by electrodeposition of PdAu nanoparticles on Polypyrrole customized carbon fiber paper electrode. The proposed technique was successfully applied in the non-enzymatic determination of MMA at an ultralow degree in human blood product and pee examples.

Source link: https://pubag.nal.usda.gov/catalog/6889816


Age-specific reference ranges are needed to interpret serum methylmalonic acid concentrations in the US population

The goal of this research was to explain the circulation of serum vitamin B-12 and MMA in US adults, and estimate age-specific recommendation intervals for serum MMA in a healthy subpopulation with abundant vitamin B-12 status and normal kidney function. In both bivariate and multivariate evaluations, age, race/Hispanic origin, and vitamin B-12 supplement usage were typically significantly related to lotion vitamin B-12 and MMA concentrations. Product MMA focus enhanced with age, specifically face to faces aged ≥ 70 y. Non-Hispanic white persons had reduced vitamin B-12 and greater MMA focus than non-Hispanic black individuals. The higher lotion MMA focus throughout the whole distribution in older individuals who are vitamin B-12-- replete and have normal renal function suggest the need for age-specific MMA reference intervals to much better analyze vitamin B-12 condition in epidemiologic research study.

Source link: https://pubag.nal.usda.gov/catalog/6725731


Methylmalonic Acid and Homocysteine as Indicators of Vitamin B12 Deficiency in Patients with Gastric Cancer after Gastrectomy

We contrasted MMA and homocysteine degrees of patients with stomach cancer after gastrectomy with controls and evaluated the occurrence of vitamin B12 shortage making use of MMA and homocysteine in patients. Of the 151 patients examined after gastrectomy, 32 patients were vitamin B12 deficient as defined by lotion MMA degrees > 350 nmol/L, and 8 patients were vitamin B12 deficient as defined by serum homocysteine levels > 15 μmol/ L. Among 33 patients with raised MMA or homocysteine degrees, 8 patients were vitamin B12 lacking based on a lotion vitamin B12 level < 200 pg/mL. These outcomes suggest that utilizing serum vitamin B12 levels alone might fall short to spot vitamin B12 deficiency. Additional assessments of MMA and homocysteine levels serve to examine feasible vitamin B12 shortage in patients who went through a gastrectomy, and MMA is a better indication than homocysteine to spot very early modifications in vitamin B12 degrees.

Source link: https://pubag.nal.usda.gov/catalog/6506978


Methylmalonic Acid and Homocysteine as Indicators of Vitamin B12 Deficiency in Patients with Gastric Cancer after Gastrectomy

We compared MMA and homocysteine levels of patients with stomach cancer after gastrectomy with controls and reviewed the prevalence of vitamin B12 shortage using MMA and homocysteine in patients. Among 33 patients with raised MMA or homocysteine degrees, 8 patients were vitamin B12 deficient based on a product vitamin B12 level < 200 pg/mL. The typical MMA degree was greater in patients with post-gastrectomy compared to pre-gastrectomy, while the mean product homocysteine degree was not considerably various. These outcomes suggest that utilizing serum vitamin B12 degrees alone might fall short to find vitamin B12 shortage. Added assessments of MMA and homocysteine levels are beneficial to evaluate possible vitamin B12 deficiency in patients who went through a gastrectomy, and MMA is a better indicator than homocysteine to spot early changes in vitamin B12 levels.

Source link: https://pubag.nal.usda.gov/catalog/6507234


Impact on Isoleucine and Valine Supplementation When Decreasing Use of Medical Food in the Nutritional Management of Methylmalonic Acidemia

Approaches: A chart evaluation, of patients aged 31 days or older with MMA treated with dietary intervention and supplementation of VAL and/or ILE and followed at the Children's Hospital Colorado Inherited Metabolic Diseases Clinic. Results: Baseline suggest complete healthy protein intake for five patients was 198% of Recommended Dietary Allowance with 107% all-natural protein and 91% clinical food. Adhering to intervention, overall protein intake, protein from clinical food, and leucine from medical food were lower, without any substantial change in natural healthy protein intake. There was no statistically considerable distinction in plasma propiogenic amino acid concentrations.

Source link: https://pubag.nal.usda.gov/catalog/7034309


Nutritional Management and Biochemical Outcomes during the Immediate Phase after Liver Transplant for Methylmalonic Acidemia

Lately, liver transplant became a treatment option for MMA patients. However, there has been no present agreement on the post-operative nutrition monitoring for MMA patients undertaking transplant, specifically throughout the initial phase of recuperation period with catabolic stress factors. We carried out a retrospective analysis of nutritional and medical administration along with biochemical accounts before and after LT in five patients with MMA. Through this research, we observed substantial renovation of MMA-associated metabolites after LT. MMA patients were able to endure boosted undamaged protein consumption post-operatively.

Source link: https://pubag.nal.usda.gov/catalog/7153504


Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations

The goal of this research study was to compare the impacts of parenteral versus oral cobalamin supplements on lotion methylmalonic acid and homocysteine focus in dogs with hypocobalaminaemia. Thirty-six pets with lotion cobalamin concentrations below 285ng/L were treated with PO or PE cobalamin utilizing a block-randomized routine. Product MMA and HCY focus were evaluated at day 0, 28 and 90 after beginning of supplementation. There was no significant distinction between the PO and PE group relating to product MMA or HCY concentrations at any kind of time point.

Source link: https://pubag.nal.usda.gov/catalog/6230281

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions