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Methylenetetrahydrofolate Reductase - Europe PMC

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Last Updated: 13 April 2022

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Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and H-type hypertension: A systematic review and meta-analysis.

To determine the relationship between the MTHFR C677T polymorphism and H-type hypertension, the MTHFR C677T polymorphism and H-type hypertension was used with a 95% confidence interval. With the homozygous codominant model, the predominant model, recessive model, and the allelic model, MTHFR C677T polymorphism and H-type hypertension were linked to MTHFR C677T polymorphism and H-type hypertension, according to the meta-analysis results. MTHFR C677T polymorphism has a positive correlation with the risk of H-type hypertension. Conclusion In summary, our findings support the belief that the MTHFR C677T polymorphism is related to H-type hypertension susceptibility.

Source link: https://europepmc.org/article/MED/35394066


Central Retinal Vein Occlusion in 12-year-old Girl with Methylenetetrahydrofolate Reductase Mutation: A Case Report and Review of the Literature.

Purpose This case report describes a central retinal vein occlusion in a healthy 12-year-old girl who experienced retinal vein occlusion at 24 years of age. To our knowledge, this is the longest time between a confirmed pediatric CRVO event and neovascularization. To date, there have been no further ocular or systemic thrombotic events. Pediatric patients with CRVO should have a systemic examination and follow-up to prevent problems such as intraocular hemorrhage, tractional retinal detachments, and neovascular glaucoma.

Source link: https://europepmc.org/article/MED/35385432


Variable neurological phenotypes of homocystinuria caused by biallelic methylenetetrahydrofolate reductase variants.

A variety of disorders, including homocystinuria, can be related to inherited methylenetetrahydrofolate deficiency. This paper aims to describe the clinical phenotypes and molecular characteristics of patients with homocystinuria caused by biallelic variants of MTHFR. MTHFR deficiency patients with varying neurological phenotypes could be viewed as a continuum. Fatal infantile encephalopathy was found in one family, but another patient presented with acute leukoencephalopathy for 27 years and recovered within three months within a short period of time. Four patients were treated with betaine, B12, and folic acid with mixed results.

Source link: https://europepmc.org/article/MED/34845156


Evaluation of umbilical cord immune cells in pregnancies with autoimmune disorders and/or methylenetetrahydrofolate reductase polymorphisms.

Objects: To determine umbilical cord immune cells in pregnancies with autoimmune disease and/or methylenetetrahydrofolate reductase polymorphisms, it should be determined. Methods Umbilical cords were obtained from seven AID women without MTHFR polymorphisms, eight with AID and MTHFR polymorphisms, eight with MTHFR polymorphisms, nine with MTHFR polymorphisms, nine with MTHFR polymorphisms, eight with MTHFR polymorphisms, nine with MTHFR polymorphisms, eight with MTHFR polymorphisms, nine with MTHFR polymorphisms, eight women without MTHFR polymorphisms, eight AID and MTHFR polymorphisms, eight with MTHFR polymorphisms, eight with MTHFR polymorphisms MTHFR polymorphisms MTHFR polymorphisms MTHFR polymorphisms MTHFR polymorphisms, eight MTHFR polymorphisms MTHFR polymorphisms MTHFR polymorphisms MTHFR polymorphisms, eight with MTHFR polymorphisms, eight with MTHFR polymorphisms In six umbilical cord zones, anti-CD4, anti-CD8, anti-CD19, anti-CD21, anti-CD19, anti-CD21, and anti-CD56 antibodies were tested immunohistologically, including 1 arterial wall 2 perimenous zone 5 intervascular zone and a 6 subamniotic zone. The presence of maternal risk factors is significantly affected by CD8+ cell population. Only cells were observed in the control group's arterial wall and the intervascular zone of the AID group with different morphologic characteristics. Conclusions MTHFR polymorphisms and/or AID can influence the stem cell and immune cell composition in a variety of risk factors such as MTHFR polymorphisms and/or AID.

Source link: https://europepmc.org/article/MED/35344642

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions