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Streptomyces DNA replication begins with the DnaA, which is linked to the source of replication. SCO2102-mCherry frequently co-localizes with FtsZ-eGFP during sporulation, significantly reducing FtsZ-eGFP Z-ladder formation, revealing a role for SCO2102 in sporulation. SCO2102-mCherry co-localizes with SCO2103-eGFP during sporulation, and SCO2102 is crucial for the SCO2103 positioning at sporulating hyphae, since SCO2103-eGFP fluorescent spots are absent in the SCO2102 knockout. SCO2102 is the first protein containing a DnaA II domain specifically found during sporulation, according to the authors, whereas SCO2103 is the first methylenetetrahydrofolate reductase found to be essential for Streptomyces sporulation.
Source link: https://doi.org/10.3390/ijms23094984
Of the research conducted in Africa, only two studies showed a strong correlation between the MTHFR and the risk of developing HTN. MTHFR and the risk of developing HTN were found in studies conducted in other continents, while the remaining studies did not reveal a significant relationship. An obvious association between rs1801133 and HTN in global regions has been established by literature; however, such evidence is still lacking in Africa, particularly among the black African population.
Source link: https://doi.org/10.3390/genes13040631
Abstract Background Cerebral ischemia is a complex of reactions that may have a large effect on the final volume of a brain infarction. In 128 patients with non-lacunar ischemic strokes, we analyzed the C677T polymorphism in the MTHFR gene and the C419A polymorphism in the GSTO-1 gene. Results We found no significant correlation between MTHFR or GSTO-1 polymorphisms with cerebral infarct volume, which contradicts cerebral infarct volume. Conclusions No significant gene change of either the MTHFR or GSTO-1 genes as a predictor of ischemic stroke volume has been found in our study.
Source link: https://doi.org/10.1186/1471-2377-9-37
Abstract Background: Cigarette smoking is a well-known risk factor of lung cancer risk, according to the latest epidemiological studies, an elevated lung cancer risk associated with alcohol consumption is correlated with increased lung cancer risk. We investigated whether smoking or alcohol intake affected MTHFR polymorphisms and lung cancer risk. Methods We investigated the role of MTHFR C677T and A1298C polymorphisms in a case-control study involving 462 lung cancer cases and 379 controls in a Japanese population. C677T polymorphism's genotype was highly correlated with an elevated risk of lung cancer in the case, whereas the A1298C polymorphism was not related to lung cancer risk. Conclusions The C677T polymorphism was significantly related to lung cancer risk, according to lung cancer risk. Future studies that incorporate data on folate intake may lead to a more comprehensive understanding of lung cancer development by the MTHFR polymorphisms.
Source link: https://doi.org/10.1186/1471-2407-11-459
MTHFR at position 677 was higher among control mothers, but no effect was found on DS pregnancy risk. Similarly, neither the homozygous CC genotype frequency at position 1298 nor the heterozygous AC genotypes point to a higher risk of DS at a statistically significant level.
We used unrelated and family-based case-control study designs to see if the C677T variant of the MTHFR gene is related to migraine susceptibility. To determine whether the MTHFR gene variant C677T is associated with migraine susceptibility, we used unrelated and family-based case-control study designs to determine whether the MTHFR gene's C677T variant is related to migraine susceptibility. Methods In this report, a total number of 652 Caucasian migraine cases were investigated. The MTHFR C677T genotype was tested in 270 unrelated migraine cases and 270 controls, as well as 382 affected subjects from 92 multiplex pedigrees. Conclusions In the unrelated case-control study, we found an overrepresentation of the 677T allele in migraine patients compared to controls, particularly for the MA subtype. The Armitage test for trend showed a significant dosage effect of the risk allele for MA. Overall, our results reveal that the T/T genotype causes a modest yet significant rise in risk for the MA subtype. MTHFR enzymes' discovery as well as the role of homocysteine in migraine pathophysiology is warranted.
Source link: https://doi.org/10.1186/1741-7015-2-3
High homocysteine levels may be embryotoxic and contribute to reduced fetal viability, according to the firm's relationship with increased homocysteine levels and neural tube defects. In this review, I focus on recent studies on the role of hyperhomogene-associated polymorphisms in human spontaneous abortion development, as well as the possibility that periconceptional supplementation with folate and vitamin B 12 might reduce the risk of miscarriage in women planning a pregnancy.
Source link: https://doi.org/10.1186/1477-7827-2-7
To determine the best interaction combination among four SNPs within the MTHFR gene, nicotine or alcohol consumption, a generalized multifactor dimensionality reduction was used. Results: The prevalence of the rs484649-A allele was 28. 6% in IS patients and 19. 1% in normal controls, but in addition, the rs3737968-T allele was 27. 9% in IS patients and 20. 3% in normal controls, which was also showing a statistically significant difference. The GMDR model found a robust gene–alcohol interacting system combination, but there were no specific gene–tobacco smoking interaction combinations. We performed stratified analysis for interaction effect using logistic regression to determine the odds ratios and 95% CI for the joint effects of gene–alcohol consumption on IS. After adjusting for age, smoke, and smoking status, we discovered that alcohol drinkers with a rs4846049-CA/AA genotype also have the highest IS risk, compared to never drinkers with a rs4846049-CC genotype, OR = 3. 12.
Source link: https://doi.org/10.4103/aian.AIAN_192_19
This study aims to determine MTHFR C677T and A1298C gene polymorphism in Indonesian infertile men with azoospermia and oligozoospermia. Methods: This cross-sectional research uses 3 mL of blood from 150 infertile men with oligozoospermia and azoospermia. Results: The results show that the distribution of allotypes of MTHFR gene SNP A1298C and A677T is not significantly different between patient groups with oligozoospermia and azoospermia, as shown by the presenters. MTHFR gene polymorphisms, both of SNP A1298C and C677T, are not associated with male infertility in Indonesian men, including patients with severe oligozoospermia and azoospermia.
Source link: https://doi.org/10.13181/mji.v21i1.470
Anatomical characteristics of testis in y-c and yak were similar, except for the fact that the y-c's weight or size was much higher or larger than yak's. The encoding 655 amino acids in y-c, an open reading frame for the 2600 nucleotides sequence, showed good homology with zebu cattle and wild yak. MTHFR mRNA expression in y-c and yak was significantly higher in adult testes than in juvenile ones, and it was significantly higher in y-c and yak. In adult y-c and yak, the protein expression was higher, but not statistically significant, but not significantly different than the juvenile ones.
Source link: https://doi.org/10.3390/ani10101731
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