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Methyl Guanine Dna - DOAJ

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Last Updated: 15 November 2021

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The effects of O6-methyl guanine DNA-methyl transferase promotor methylation and CpG1, CpG2, CpG3 and CpG4 methylation on treatment response and their prognostic significance in patients with glioblastoma

This retrospective study analyzed the prognostic importance and treatment impact of marketer methylation of O6- methyl guanine methyl transferase and meth-ylation of CpG 1, CpG2, CpG3 and CpG4 in glioblastoma patients obtained postoperative radiotherapy, with or without adjuvant temozolomide. One hundred patients with GB who received PORT with concomitant TMZ plus adjuvant TMZ or PORT alone, were consisted of. The methylation of each CpG1, CpG3, cpg4 and cpg2 islands was located to have no considerable effects on OS and the methylation of each CpGl, CpG2 and CpG4 islands had no considerable result on PFS. In the team that just received radiotherapy, cpc3 and cpg1 methylations were found to have a positive prognostic importance in regards to PFS.

Source link: https://doi.org/10.2478/bjmg-2020-0015

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions