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Methyl - PLOS

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Last Updated: 20 June 2022

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Age and sex effects on DNA methylation sites linked to genes implicated in severe COVID-19 and SARS-CoV-2 host cell entry

"CpGs related to SARS-CoV-2 host cell entry genes were all linked to age and sex, except for the ACE2 receptor gene, which was only linked to sex. " The CpGs associated with host-cell entry and severe COVID-19 were not more or less associated with sex than the CpGs collected from random genomic regions, but it was found to be less so. Hence, although we found widespread correlations between sex and age at CpGs connected to genes linked to SARS-CoV-2 host cell entry and severe COVID-19, it was not significantly different than that obtained from randomly sampled CpGs, in age; for age, it was less so. ".

Source link: https://doi.org/10.1371/journal.pone.0269105


Differential effects of excess high-fructose corn syrup on the DNA methylation of hippocampal neurotrophic factor in childhood and adolescence

"Consumtion of fructose-containing beverages such as high-fructose corn syrup is on the rise," triggering questions regarding adverse effects of heavy fructose intake. " In three age groups, childhood and adolescence, young adulthood, and late adulthood — we investigated the effects of HFCS intake on hippocampal development. Male Sprague-Dawley rats were divided into three age groups, the control group was given distilled water, and the HFCS group received 20% HFCS for 40 days in each period. In childhood and adolescence, HFCS consumption reduced hippocampal Bdnf mRNA and protein expressions. In addition, pyrosequencing assays revealed increased DNA methylation at the Bdnf promoter in childhood and adolescence. The sensitivity of the hippocampus to fructose may change with age, according to our findings. "This report provides insight into the adverse effects of heavy HFCS intake on children's hippocampus. ".

Source link: https://doi.org/10.1371/journal.pone.0270144


Investigating the structural changes due to adenosine methylation of the Kaposi’s sarcoma-associated herpes virus ORF50 transcript

The human oncovirus "Kaposiyu2019s sarcoma-associated herpes virus is a human oncovirus. " To increase virus replication, the host cell's N6-methyl adenosine RNA modification pathway is used by KSHV. We investigate the effect of methylation on ORF50's stem loop structure in this series. Since RNA systems must be able to reproduce a specific 3D shape, it is vital to know how a chemical modification will affect the structure adopted. We're able to characterize the RNA before and after the upgrade, as well as knowing what the key differences between the ensembles of structures, which can be adopted by the system, are" thanks to the computational technique of energy landscape explorations, which is investigating what structures are available to the system at a given energy.

Source link: https://doi.org/10.1371/journal.pcbi.1010150

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions