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Methotrexate leukemia Toxicity - Crossref

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Last Updated: 02 May 2022

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Is hypoalbuminemia a risk factor for high-dose methotrexate toxicity in children with acute lymphoblastic leukemia?

Abstract Background Theme of Childhood Chronic Lyoblastic Leukemia Treatment regimens use repeated high-dose methotrexate. This research was designed to investigate the relationship between pre-infusion serum albumin and potential HDMTX toxicities. In the first consolidation cycle, Plasma MTX levels were expected at 24 h from the start of HDMTX infusion in the first consolidation cycle. Before HDMTX administration, serum albumin level was established, but pre-infusion hypoalbuminemia was identified when serum albumin was less than 3. 5 g/dL. Oral mucositis was more prevalent in the 2. 5 g/m2 than the 5 g/m 2 HDMTX cycles. Conclusions: Serum albumin levels should be tested before starting HDMTX cycles, particularly in resource-limited settings, where malnutrition is common, and serum MTX testing may not be available. Optimizing serum albumin levels before HDMTX therapy may reduce the risk of HDMTX-toxicities.

Source link: https://doi.org/10.1186/s43046-022-00122-7

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions