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Methotrexate leukemia Polymorphism - Europe PMC

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Last Updated: 02 November 2021

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A Risk Scoring Model for High-Dose Methotrexate-Induced Liver Injury in Children With Acute Lymphoblastic Leukemia Based on Gene Polymorphism Study.

A research on 70 intense lymphoblastic leukemia children treated with high-dose methotrexate in Sichuan Provincial People's Hospital was performed. The objective of the research was to develop a risk-scoring version to forecast HD-MTX-induced liver injury, considering genetics polymorphisms' results. The risk-scoring design was established by ridge regression and examined the forecast efficiency. Inevitably, the danger ratings were stratified into 3 teams based on their distributions: reduced-, tool-, and risky groups. This research study can provide knowledge for the prediction of HD-MTX-induced liver injury and reference for the medical medication.

Source link: https://europepmc.org/article/MED/34658865

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions