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Methotrexate Psoriasis - Crossref

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Last Updated: 02 May 2022

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Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature

Patients with immunosuppression are multigeneous clinicopathological disorders with isolated immune deficiency-associated lymphoproliferative disorders. Methotrexate, a drug commonly used to treat autoimmune diseases, is an immunosuppressive agent commonly associated with LPD outside of the post-transplant setting, and it has been linked to LPD. Spontaneous recovery of LPD after MTX withdrawal is typical of MTX-LPD, so avoiding chemical therapy in a significant number of patients is a risk.

Source link: https://doi.org/10.1155/2022/7178065


Sex-differential downregulation of methotrexate on plasma viscosity and whole blood viscosity in psoriasis

Methotrexate is often used as a first-line system therapy, but in psoriasis, there is a need to determine its effect on complete blood viscosity and plasma viscosity. METHODS is a prospective, single-center interventional study involving 111 patients who received MTX therapy from October 22, 2018, to December 28, 2019, and 111 age- and sex-matched healthy controls. However, only hCRP was positively associated with a psoriasis area severity index score. CONCLUSION: The effect of MTX on WBV, PV, hCRP, and BP was linked to sex, and BP, showing that the effect of MTX on cardiovascular disease was tied to sex.

Source link: https://doi.org/10.3233/ch-211343


Immunomodulatory Effect of Methotrexate Abruptly Controls Keratinocyte Activation in Psoriasis

Epidermal keratinocytes are deregulated in psoriatic skin, resulting in the release of inflammatory mediators and abnormal keratins. Psoriasis is caused by a vicious cycle of KC-immune responses. Epidermal KCs are subjected to a deregulated immune response that results in prolonged expression of inflammatory mediators and abnormal keratins in psoriatic skin, epidermal KCs. Psoriasis can be caused by these novel keratin mutations in psoriatic epidermis, which may be one of the triggering factors for psoriasis. MTX is a CDC affiliate that controls the KC activation cycle by tightly controlling inflammatory markers and maintaining normal keratin phenotype on hyperproliferating KC, thus limiting acanthosis in psoriasis patients.

Source link: https://doi.org/10.5772/intechopen.102811


MTHFR Gene Polymorphism Association With Psoriatic Arthritis Risk and the Efficacy and Hepatotoxicity of Methotrexate in Psoriasis

Aims To determine whether MTHFR rs1801131 and rs1801133 SNPs are related to concomitant psoriatic arthritis, as well as other asymptomatic psoriatic arthritis patients, and to investigate the equival and hepatotoxicity of MTX in Han Chinese patients with psoriasis. PsA patients with PsA were more frequent in rs1801133 CC genotypes than those with PsO and healthy controls. Patients with the rs1801133 TT genotype were significantly higher in MTX patients than those with the CT and CC genotype, with the 90 percent change from baseline PASI response rates to MTX. The rs1801133 CT+TT genotype was more prevalent in PsA patients with abnormal liver function than in those with normal liver function. Conclusions This research provided some evidence for MTHFR polymorphism association with PsA risk as well as the use of PsA and the low-dose MTX's efficacy and hepatotoxicity in the Chinese population.

Source link: https://doi.org/10.3389/fmed.2022.869912


Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis

Psoriasis is a persistent inflammatory skin disease. This work examined two MTX-loaded LPs based on stearic acid, cholesterol, and ceramides, as well as topical treatments for mice with imiquimod-induced psoriasis. C1CH and C1CHCE were topically administered to mice with imiquimod-induced psoriasis. As a positive health monitor, Dexamethasone cream was used as a positive treatment control. The epidermis and dermis were shown to have visible immunomodulatory activity, as well as extensive microstructural skin remodelling.

Source link: https://doi.org/10.1093/jpp/rgac006

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions