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Methotrexate Azathioprine - Europe PMC

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Last Updated: 09 May 2022

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Mucosal healing with methotrexate versus azathioprine treatment in pediatric Crohn's disease as reflected by fecal calprotectin.

Background/objectives The current treatment target for inflammatory bowel disease is the result of mucosal healing. Since the company was not established with biologic or azathioprine therapies, the data on MH with methotrexate MTX therapy is lacking. We set out to compare MH rate as shown by FC in children with Crohn's disease treated with either MTX or thiopurines monotherapy. Methods An intercollegiate multicenter study included children with CD, and reported mucosal ulcerations/erosions on their first endoscopy, were in clinical and biochemical remission for at least six months, with fecal calprotectin measurements during remission, with documented calprotectin measurements during remission. The mean therapy duration was 22 17. 1 months, with 1. 8 mg/m2 for MTX and 1. 8 mg/kg for AZA. Conclusions MH as reflected by FC 100 g/gr was higher with AZA/6-MP compared to MTX therapy in pediatric CD, as shown by FC 100 g/gr.

Source link: https://europepmc.org/article/MED/35373937


Effect of gervital in attenuating hepatotoxicity caused by methotrexate or azathioprine in adult albino rats.

This review looked at the role of grape seed extract in attenuating hepatotoxicity caused by MTX or AZA treatment. Rats were divided into six groups, Group I, the normal control group; Group II, GSE; Group III, MTX; Group IV, AZA; Group IV, GSE; Group III, AZA; Group IV, MTX; Group III, GSE; Group III, AZA; Group VI, GSE + MTX; and Group VI, GSE + AZA ; Group I; Group III, AZA ; Group III, AZA ; Group III, Chronic liver disease, elevated relative liver weight, boosted the activity of glutamate pyruvate phosphatase and glutamate oxaloacetate transaminase and aspartate aminotransferase, as well as other skeletal changes, as well as histopathological and ultrastructural changes as a result of histopathological changes during MTX and AZA therapy, as well as increased blood pressure, increased relative liver weight, oxal Reduced glutathione, catalase, and superoxide dismutase, as well as elevated malondialdehyde concentrations were found in the liver under severe oxidative stress. GSE therapy also reduced MDA levels, but raised the antioxidant parameters. In conclusion, it was found that GSE supplementation could be a promising antioxidant in lowering OS, histopathological, and ultrastructural changes induced by MTX and AZA.

Source link: https://europepmc.org/article/MED/35169948


Impact of Gervital Against Histopathological, Ultrastructural, and Biochemical Alterations Caused by Methotrexate or Azathioprine in Albino Rats Testis

Methotrexate and azathioprine are chemotherapeutic, immunosuppressive, and cytotoxic drugs with reported adverse effects such as oxidative damage to testis. This research aims to investigate the possibility of grape seed extract in the hopes of preventing testicular injury caused by MTX and AZA. Rats were divided into six groups by Group I, the central control group; Group II, GSE; Group III, MTX; Group II, Group III, MTX ; Group III, MTX. GSE + MTX, Group V, GSE + MTX; Group VI, GSE + MTX; GSE + MTX ; GSE+ MTX; GSE + MTX; Group VI, GSE + AZA testosterone, histopathological, and ultrastructural changes in the GSE administration had an ameliorating effect on testosterone, histopathological, and ultrastructural changes. The rise in MDA levels and the decrease in GSH level, CAT, and SOD outcomes were also reduced by GSE therapy, which also reduced the rise in MDA levels and SOD levels. Our results showed that GSE is a safe antioxidant that protects testis and shields it from the histopathological and ultrastructural damage caused by MTX and AZA. So, GSE is a promising candidate for future use to minimize and eliminate MTX and AZA risks, so it's a promising candidate for future use to minimize and eliminate MTX and AZA risks.

Source link: https://europepmc.org/article/PPR/PPR452039

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions