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Methionine Synthase - DOAJ

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Last Updated: 13 February 2022

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Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms and associated risk of cardiovascular diseases: A study from Jammu region

Methionine and S-adenosine methionine synthesis takes place by a central role in Methionine and S-adenosine methionine synthesis. The homocysteine remethylation reaction is identified by Methylenetetrahydrofolate reductase and methionine synthase genes, as well as elevated homocysteine levels, which are also linked to a variety of cardiovascular phenotypes. In the population of Jammu, J&K state's north-east area, we wanted to conduct a research on the relationship of MTHFR and MTR gene polymorphism with CVD. MTHFR C677T and MTR A2756G gene polymorphism was achieved by PCR-RFLP technique. Results: Patients' serum LDL-C, TC, and TG were all significantly elevated in patients, compared to controls, although serum HDL-C was higher in controls. The analysis of genetic association revealed that MTHFR C6877T and MTR A2756G polymorphisms were associated with a higher risk of CVD. Conclusion: The current report reveals significant differences in nongenetic parameters among patients and controls, as well as the association of gene polymorphisms with CVD risk.

Source link: https://doi.org/10.1016/j.ihj.2016.02.009


Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence

ABSTRACT This is the reason fungal pathogens pose to human health is urgently needed to create novel antifungals to combat the threat that fungal pathogens pose to human health. In Aspergillus fumigatus, the absence of this enzymatic activity leads to a metabolic imbalance that results in a decrease in intracellular ATP, which prevents fungal growth even in the presence of methionine. According to our reports, we have confirmed the use of the tetOFF genetic tool in fungal research and increased its success in vivo to obtain initial validation of targets in models of established infection. In vitro, we show that metH reduction in growing hyphae halts growth, which turns into a positive result when fighting endemic infections using this model in vivo. Until recently, a computer-based virtual screening of methionine synthases reveals key differences between the human and fungal structures, as well as the discovery of novel specific inhibitors. IMPORTANCE Fungal pathogens are responsible for millions of life-threatening infections on an annual basis worldwide. The first step to produce new drugs is often to identify molecular targets in the pathogen's infection that can prevent growth. In addition, we have optimized the use of a genetic device to have a beneficial effect of attacking methionine synthase in established infections. We therefore recommend that antifungal drugs targeting methionine synthase be pursued, and that, in addition, a framework that allows researchers to obtain data regarding the validity of antifungal targets in established infections.

Source link: https://doi.org/10.1128/mBio.01985-20

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions