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We researched the expression and regulation of the methionine sulfoxide reductases that are included in the fixing of oxidized staphylococcal proteins and explored their impact on the destiny of S. aureus revealed to oxidants or PMN. The guideline of msr was researched by screening a library of two-component regulatory system mutants for transformed msr responses. Upregulation of staphylococcal msrA1 occurred within the phagosomes of normal PMN and PMN lacking in NADPH oxidase task. Our research study highlights a novel communication between the oxidative protein repair service pathway and the VraSR TCS that is involved in cell wall homeostasis.
Source link: https://doi.org/10.1159/000355915
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