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Methicillin-resistant Staphylococcus - Springer Nature

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Last Updated: 02 May 2022

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Suppression of Thiol-Dependent Antioxidant System and Stress Response in Methicillin-Resistant Staphylococcus aureus by Docosanol: Explication Through Proteome Investigation

The present research was designed to find out the effects of docosanol on the protein expression profiles of methicillin-resistant Staphylococcus aureus. From the intracellular proteome of both control and docosanol treated samples, a total of 947 protein spots were found, among which 40 spots were differentially classified with a fold change greater than 1. 0. Docosanol reduced the expression of proteins involved in purine metabolic pathways, biofilm growth cycle, and virulence factor production in addition. These results, according to Altogether, these results indicate that docosanol could effectively target the antioxidant pathway by lowering the expression of bacillithiol and stress-associated proteins.

Source link: https://doi.org/10.1007/s12033-021-00434-4


Metal nanoparticles functionalized with nutraceutical Kaempferitrin from edible Crotalaria juncea, exert potent antimicrobial and antibiofilm effects against Methicillin-resistant Staphylococcus aureus

KF@AgNPs and KF@CuNPs' effectiveness against biofilm assembly and planktonic growth on methicillin-resistant Staphylococcus aureus has been investigated as well as potential mechanisms. The CuNPs' antibacterial activity was triggered by the CuNPs' persistent treatment with KF@CuNPs in the presence of MRSA, according to an Alizarin red test, indicating that the CuNPs' antibacterial activity was initiated by the CuNPs itself. With Crystal violet assay, Fluorescent live dead imaging and SEM results, a 60% decrease in biofilm formation at KF@AgNPs and KF@CuNPs showed that both the NPs had similar kill kinetics to reduce the pathogen and imaging. The colony count from the in vivo infection zebrafish model in the treatment group decreased by > 1. 8 fold for KF@AgNPs and > twofold for KF@CuNPs. When treated with KF@AgNPs and were almost identical to the normal liver, no significant cytological changes were apparent, as shown by liver morphology images.

Source link: https://doi.org/10.1038/s41598-022-11004-2


Everybody nose: molecular and clinical characteristics of nasal colonization during active methicillin-resistant Staphylococcus aureus bloodstream infection

Background Healthcare-associated infections such as Staphylococcus aureus are a potentially lethal threat to patients around the world, and healthcare-associated infections related to healthcare-associated infections include Staphylococcus aureus. MRSA growth was evaluated in a single colony culture from the blood and an average of 6 colonies from the nares. MRSA bloodstream infection, 53 were swabbed, and 37 were colonized with MRSA in the anterior nares, indicating an 11-month course. In 95% of the cases, spa types and clonal complexes were also present in the blood. In the nares, 11% of patients had more than one clone of MRSA. Conclusions The molecular epidemiological landscape of colonization in the context of invasive disease is varied, and determining the interplay between colonization and invasive disease is crucial in combating invasive MRSA disease is key to combating invasive MRSA infection.

Source link: https://doi.org/10.1186/s12879-022-07371-w


Inhibition of Berberine on Methicillin-Resistant Staphylococcus aureus Biofilm Formation

This review looked at the effect and potential mechanism of berberine production by methicillin-resistant Staphylococcus aureus. The minimum inhibition concentration and minimum bactericidal concentration for berberine were both 0. 05 mg/ml and 0. 1 mg/ml, respectively, in comparison to chloramphenicol. In addition, berberine significantly increased biofilm production and reduced biofilm thickness in a dose-dependent manner.

Source link: https://doi.org/10.1007/s43450-022-00242-0


Methicillin-resistant Staphylococcus aureus enterocolitis in a 16-month-old boy: a case report

Staphylococcus aureus enterocolitis, a rare disease that usually affects immunocompromised adults, is characterized by a rare disorder. Gram-negative bacteria, Gram-positive Clostridiodes difficile, or viruses are the most common causes of pediatric enterocolitis. This is the first published case report of a toddler with methicillin-resistant Staphylococcus aureus enterolitis. Case description The 16-month-old non-Hispanic White boy with no previous medical or psychosocial history was first admitted to the emergency room with abdominal pain and emesis. The patient had recurrent symptoms on the following day, and a repeat contrast enema revealed no signs of recurrent intussusception. An antibiotic leak on hospital day 6 delayed his postoperative course, necessitating reoperation and the development of an end ileostomy with mucous fistula. The patient experienced a sudden rise in ileostomy production on postoperative day 12, and stool cultures were established. Three days later, stool cultures tested negative for Escherichia coli, Salmonella, Shigella, Campylobacter species, and Clostidiodes difficile, but not positive for methicillin-resistant Staphylococcus aureus. The patient was started on a 10-day course of oral vancomycin and discharged home in good health four days later. Conclusions This is the first published study of a child diagnosed with methicillin-resistant Staphylococcus aureolitis aureus enterolitis. Enterocolitis, a methicillin-resistant Staphylococcus aureus, is uncommon and has overlapping signs with more common gastrointestinal pathologies, and it is often misdiagnosed. When a patient has diarrhea or high ostomy production, as well as fecal cultures that are resistant to Clostridiodes difficile and other common pathogenic agents, methicillin-resistant Staphylococcus aureus should be considered.

Source link: https://doi.org/10.1186/s13256-022-03381-z


Antibacterial and Antibiofilm Activity of Mercaptophenol Functionalized-Gold Nanorods Against a Clinical Isolate of Methicillin-Resistant Staphylococcus aureus

The seed-mediated wet chemical reaction proceeded gold nanorods were synthesized by a binary surfactant system. 4-MPH-AuNRs' antibacterial and antibiofilm activities were investigated against a Methicillin-Resistant Staphylococcus aureus clinical isolate. 4-MPH-AuNRs have bactericidal activity against a planktonic suspension of MRSA, indicating minimum inhibitory concentration of 6. 25 g/mL. In addition, 4-MPH-AuNRs resulted in a 1. 8–2. 9 log-cycle decrease of MRSA biofilm viable count over a concentration range of 100–6. 0 g/mL. The surface-modified nanorods were found to be internalized into the bacterial cells after 6 hours of exposure, according to the findings, the nanorods were embedded into the bacterial cells by inductively coupled plasma-optical emission spectroscopy and scanning electron microscopy imaging. SEM imaging revealed a significant accumulation of the nanorods at the bacterial cell wall and a potential cell internalization. Consequently, 4-MPH-AuNRs can be used as a potential antibacterial agent, particularly against MRSA strain biofilms.

Source link: https://doi.org/10.1007/s10904-022-02294-0

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions