Methicillin-Resistant Staphylococcus Aureus - Wiley Online Library

Bacterial toxin‐triggered release of antibiotics from capsosomes protects a fly model from lethal methicillin‐resistant Staphylococcus aureus (MRSA) infection

Staphylococcus aureus bacterial infections are resistant to methicillin-resistant Staphylococcus aureus infections, which are specifically designed herein. MRSA-activated single drug delivery of vancomycin and synergistic dual delivery of vancomycin and synergistic dual delivery of vancomycin together with an antibacterial peptide successfully killed MRSA in vitro. Capability of capsosomes to selectively deliver their cargo in the presence of bacteria, resulting in a bactericidal action to shield the host organism, is demonstrated in vivo by using a Drosophila melanogaster MRSA infection model.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/adhm.202200036

Linearized teixobactin is inactive and after sequence enhancement, kills methicillin‐resistant Staphylococcus aureus via a different mechanism

Staphylococcus aureus, a highly adaptable pathogen, can cause rapid resistance to common antibiotics, such as penicillin. Teixobactin was first isolated soil bacteria by using the i-chip technology for the first time recently. This depsipeptide forms an ester bond between the backbone Cterminal isoleucine carboxylic acid and the hydroxyl group of threonine ranked 8. After linearization and conversion to natural amino acids, teixobactin lost its antibacterial activity. YZ105, which inhibits cell wall synthesis, targeted methicillin-resistant S. aureus membranes, based on kinetic killing, membrane permeation, depolarization, and scanning electron microscopy studies.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/pep2.24269

Risk factors for antimicrobial resistance among Staphylococcus isolated from pets living with a patient diagnosed with methicillin‐resistant Staphylococcus aureus infection

Staphylococcus aureus and Staphylococcus pseudintermedius isolated from pets living in households of people with methicillin-resistant S. aureus skin or soft tissue infections was investigated by the investigators. MRSA and other staphylococci pathogens were found cross-sectionally from a research that looked at the transmission of MRSA and other staphylococci from humans, their pets, and the environment. Based on our findings, 52% of S. audicius, 3. 3 percent of S. pseudintermedius, and 25 percent of other coagulase-positive staphylococci were identified as MDRs. Compared to S. pseudintermedius, MDR isolates were more likely to be MDR than S. pseudintermedius isolates. The results show that the causes of antimicrobial resistance in household staphylococci may vary by bacterial species, which may have repercussions for one health intervention plans for staphylococci, as well as the identification of other reverse zoonoses, such as COVID19.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/zph.12946

Difficult maintenance of serum drug concentration in methicillin‐resistant Staphylococcus aureus toxic shock syndrome during early puerperium

Staphylococcus aureus, a methicillin-resistant Staphylococcus aureus, can cause toxic shock syndrome. Following the cesarean section, two patients developed acute shock syndrome caused by MRSA shortly after. Maintaining drug concentration at optimal levels may be difficult during the early postpartum period, which may be life-threatening. To determine the right drug dose during puerperium, it is necessary to have a better understanding of the pharmacokinetics and the development of a protocol to determine the optimal drug dose during puerperium.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jog.15221

In Vivo Efficacy, Mechanistic Study and Synergistic Interaction of Precocene II with Norfloxacin against Methicillin‐Resistant Staphylococcus aureus

The chromenes precocene I and precocene II are two main constituents of A. conyzoides aerial parts. Precocene II was evaluated for its in vitro efficacy, mechanistic analysis, and synergistic interaction with norfloxacin against methicillin-resistant Staphylococcus aureus. These results were further supported by the mouse model and revealed a significant decrease in bacterial load at much lower doses of 2 and norfloxacin without toxicity at 200 mg/kg body weight. Two regulates bacterial resistance against S. aureus clinical isolates by membrane diffusion in a dose- and time-dependent manner, according to Mechanistic studies. Precocene II also damaged the bacteria's membrane, as shown by increased membrane depolarization and increased propidium iodide uptake. It also demonstrated high selectivity against S. auus over mammalian cell lines, as shown by the microscope's.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202100906

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