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When compared to normoglycaemic peers, children with type 1 diabetes have insulin resistance independent of glycaemia. Insulin resistance raises the risk of cardiovascular disease and diabetic kidney disease, as well as systemic inflammation. In adolescents with T1D, we investigated the effect of metformin on markers of inflammation and diabetic kidney disease. Whereas eGFR measured by serum creatinine increased after metformin therapy, no change was observed in cystatin C, UACR, or systemic inflammatory markers. Additional studies with objectively measuring GFR in T1D response to metformin are required.
Source link: https://doi.org/10.1111/dom.14266
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