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NK cells are skin-resident natural cytotoxic lymphocytes that identify and kill virus-infected in addition to cancer cells thanks to a balance between repressive and activating signals supplied by surface particles revealed by the target. Since NK cells are furnished with cytotoxic machinery yet lack of antigen limitation and needing to be keyed, they are nowadays acquiring focus as an alternative to T cells to be manipulated in immunotherapy. Several proof revealed that radiation treatment utilized in metastatic melanoma therapy possess immunomodulatory properties that might bring back NK cells functions within TME. Right here, we will talk about the capacity of such chemotherapeutics to: i up-regulate cancer malignancy cells vulnerability to NK cell-mediated killing, ii advertise NK cells infiltration within TME, iii target other immune cell subsets that influence NK cells activities.
Source link: https://doi.org/10.3389/fonc.2021.754541
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