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Melanoma is a relatively uncommon disease worldwide, but it has a huge presence in certain countries, such as Europe. We compared the gene expression of 6 independent tumors to the expression profile of healthy melanocytes in order to shed some light on the transcriptional profile of skin melanoma. Overall, the tumor-control transcripts were significantly different in tumors from 50 up- and 19 down-regulated transcripts. The majority of transcripts were regulated to the immune response group and proteasome, while the majority of the downregulated genes were related to cytosolic ribosomes.
Source link: https://europepmc.org/article/PPR/PPR477002
Background uveal melanoma is one of the most important factors limiting survival in patients with uveal melanoma. Enucleation samples from 15 patients with metastatic uveal melanoma, liver metastasectomy samples from 8 patients with metastatic uveal melanoma, and non-metastatic uveal melanoma controls were included in the analysis. In samples from patients with metastatic uveal melanoma patients and those with non-metastatic disease, the frequencies of HSP-27 and BRAF V600E expressions and BAP1 expression loss were higher in samples from patients with metastatic uveal melanoma patients and non-metastatic disease patients. One-unit rises in the HSP-27 expression level and BAP1 expression loss were both significantly related to 1. 375- and 7. 855-fold rises in metastasis risk, respectively. Conclusion HSP-27 and BAP1 are thought to be associated with metastasis, extending these proteins as potential treatment targets in metastatic uveal melanoma.
Source link: https://europepmc.org/article/MED/35341390
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