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Little cell carcinoma/ neuroendocrine prostate cancer cells is a uncommon and very aggressive subtype of prostate cancer cells connected with an AR-null phenotype and visceral metastases. This study presents a 44-year-old man initially identified with metastatic hormone-sensitive prostatic adenocarcinoma. The person established liver metastases and seasoned stable disease for 4 months following etoposide incorporated with cisplatin and pembrolizumab. The prostate biopsy specimen also showed pure SCC. Furthermore, whole-exome sequencing was executed on both biopsy samplings of the thoracic vertebra at the beginning of castration resistance and that of critical vesicle after numerous lines of treatment failing. Growth biopsy and IHC evaluation must be duplicated at various stages of development, due to intrapatient spatial and temporal heterogeneity of adenocarcinoma versus SCC/NEPC.
Source link: https://europepmc.org/article/MED/34646773
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