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Metastatic Tumor Heterogeneity - Europe PMC

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Last Updated: 06 November 2021

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Histo-molecular characterization of pancreatic cancer with microsatellite instability: intra-tumor heterogeneity, B2M inactivation, and the importance of metastatic sites.

Pancreatic ductal adenocarcinoma with microsatellite instability/ defective inequality fixing is the only subtype of pancreatic cancer cells with potential response to immunotherapy. The main outcomes include the first report in pancreatic cancer cells of MSI/dMMR intra-tumor heterogeneity, the presence of microsatellite-stable metastases from MSI/dMMR persistent and primary B2M genetics inactivation, which might confer resistance to immunotherapy. The chromatin remodeler ARID1A represents another possible driver gene in this context.

Source link: https://europepmc.org/article/MED/34613461

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