Metastatic Triple-Negative Breast - Springer Nature

A novel HSP90 inhibitor SL-145 suppresses metastatic triple-negative breast cancer without triggering the heat shock response

Although HSP90 is a promising target, previous inhibitors have had problems throughout manufacture, including inadequate heat shock response inducement and off-target reactions leading to toxicity. TNBC tumor growth, angiogenesis, and metastases concomitant with poor regulation of the JAK2/STAT3 signaling pathway were effectively suppressed in an orthotopic allograft model incorporating breast cancer stem cell-enriched TNBC tumors.

Source link: https://doi.org/10.1038/s41388-022-02269-y

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