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Amoeboid tumor cells produce symoglobin, RNA, caveolin-1, and the GTPase ADP-ribosylation factor 6, which are biologically active against tumor cells, endothelial cells, and fibroblasts, according to this article. In the circulation of several mouse models of prostate cancer, structures resembling large oncosomes were identified, and their prevalence was correlated with tumor formation. Migrating tumor cells also influence the tumor microenvironment and distant locations, thus accelerating advanced disease.
Source link: https://doi.org/10.1016/j.ajpath.2012.07.030
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