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Metastatic Prostate Cancer - U.S. Department of Veterans Affairs

Summarized by Plex Scholar
Last Updated: 27 June 2022

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Interferon-γ increases sensitivity to chemotherapy and provides immunotherapy targets in models of metastatic castration-resistant prostate cancer.

In vitro, we found that IFN-u03b3 treatment led to the expression of key histocompatibility class-I genes and PD-L1 in prostate cancer cells. Moreover, IFNu03b3 treatment resulted in a decrease in E-cadherin expression, resulting in an increase in sensitivity to chemotherapy in vitro. IFNu03b3 systemic pretreatment regulated HLA-A and reduced E-cadherin expression in the primary tumor, but more specifically in the metastatic site, leading to increased apoptosis and limited micrometastases in combination with paclitaxel therapy in comparison to diffuse metastatic disease in both control and monotherapy treatment groups.

Source link: https://doi.org/10.1038/s41598-022-10724-9

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions