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Metastatic Pancreatic Neuroendocrine - DOAJ

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Last Updated: 08 February 2022

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Primary site surgery for elderly patients with distant metastatic pancreatic neuroendocrine tumor: to do or not to do?

Jing Zhang,1Bachelor of Nursing, Special Medical Department, Beijing, People's Republic of China, Population;s Republic of China; the Sixth Medical Center of People's Liberation Army General Hospital, Beijing, People's Republic of China; 3Bachelor of Nursing; 4Bachelor of Nursing; Special Medical Department;s Liberation Army General Hospital, People's Republic of China; Civil Rights Army General Hospital, Beijing, People's Republic of China; People's Republic of Nursing Department of Nursing, Beijing, Civil Hospital,1Bachelor of Nursing, Special Medical Department, Special Hospital;s Republic of China;s Liberation Army General Hospital, Beijing, People's Liberation Army General Hospital, Beijing, People's Liberation Army General Hospital, People's Liberation Army General Hospital, People's Liberation Army General Hospital, People's Liberation Army General Hospital, 2Bachelor of Nursing;s Liberation Army General Hospital, Beijing, People's Liberation Army General Hospital, People's Republic of China;s Liberation Army General Hospital, People's, People's Liberation Army General Hospital, Beijing, People's Physicians with distant metastasis in elderly patients with pancreatic neuroendocrine tumor distant metastasis, according to these authors. Researchers contributed equally to this study. The Surveillance Epidemiology and the End Results database for elderly patients with distant pNET from 1973 to 2015 was published. Patients with PSS were compared to those with no PSS, indicating that their variability and survival rates were similar to those with no PSS. The survival rate between the two groups was compared again after propensity score matching, and propensity score matching was carried out. Results: In the above two groups, a total of 210 elderly patients with distant pNET was finally identified. Both before and after propensity score matching, the patients underwent PSS had improved survival outcomes both before and after propensity score matching. PSS and a higher histological grade are shown to be protective and risk factors in a multivariable Cox proportional hazard report, which are consistent and risk factors. Conclusion: PSS can benefit patients of group 1's patients with pNET distant metastasis, but no change was found in patients of the other three subgroups.

Source link: https://doaj.org/article/7aee46e4df144f89a4bb26835f0ab01c


Ramucirumab in combination with dacarbazine in patients with progressive well-differentiated metastatic pancreatic neuroendocrine tumors (RamuNET): study protocol for a multicenter single-arm trial

Abstract Background: Abstract Background: Cytotoxic chemotherapy mixtures and targeted agents are well established treatment strategies for advanced pancreatic neuroendocrine tumors. In adult advanced PNET patients, the RamuNET trial aims to establish the efficiency of dual therapy with DTIC and ramucirumab. Methods The RamuNET study was an investigator-initiated multicenter prospective single-arm trial to determine the safety of ramucirumab in combination with dacarbazine for at least six months. The sample size estimation was based on an exact binomial single-stage design, based on the assumption that 80% of the patients will achieve disease control after 6 months. PNET advanced PNET: This article explores a new therapeutic strategy utilizing a combination of cytotoxic and targeted antiangiogenic therapy in advanced PNET. If positive, this trial will serve as the basis for a controlled two-arm trial to investigate the combination of ramucirumab and DTIC against other commonly used therapies in PNET.

Source link: https://doi.org/10.1186/s12885-021-08900-7

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions