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Metastatic Pancreatic Adenocarcinoma - Europe PMC

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Last Updated: 19 May 2022

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Development of a prognostic nomogram for metastatic pancreatic ductal adenocarcinoma integrating marital status.

Previous studies have shown that marital status can influence cancer patients' overall survival, but the role in metastatic pancreatic duct carcinoma remains uncertain. This research sought to investigate the effects of marital status on the health of mPDAC patients' OS and to develop a prognostic nomogram to predict OS outcomes. The Kaplan-Meier survival study was conducted to compare survival rates based on marital status to determine differences in survival. By Kaplan-Meier's review, our results revealed significant differences in the OS of mPDAC patients with various marital statuses. Marital status, according to univariate and multivariate studies, was an independent OS-related risk in mPDAC patients. According to the data, marital status had a modest effect on predicting the OS of mPDAC patients. Marital status has been established as an independent prognostic predictor of mPDAC patients' OS, and has been established as a reliable and valid indicator to determine patient survival.

Source link: https://europepmc.org/article/MED/35504988


Response in BRCA1 mutation carrier with metastatic pancreatic adenocarcinoma treated with FOLFIRINOX.

A woman in her 50s was diagnosed with stage IV pancreatic ductal adenocarcinoma metastatic to the liver and Caroli's disease was found to have a BRCA1 germline mutation. This is the first review in the English literature demonstrating a sustained response in patients with PDAC and BRCA 1 germline mutations in a patient with PDAC and BRCA 1 germline mutations.

Source link: https://europepmc.org/article/MED/35487638


Case Report: Maintenance Nivolumab in Complete Responder After Multimodality Therapy in Metastatic Pancreatic Adenocarcinoma.

Following a complete response to combined radiofrequency ablation for the liver metastasis and radiotherapy for the pancreatic tumor, chemotherapy was stopped and maintenance therapy was started: nivolumab plus cytokine-induced killer cell therapy was administered initially, followed by a de-escalated dosing interval of nivolumab monotherapy. This is the first report of maintenance nivolumab after a successful multimodality therapy in metastatic PDAC to date.

Source link: https://europepmc.org/article/MED/35572526


Metastatic Transition of Pancreatic Ductal Cell Adenocarcinoma Is Accompanied by the Emergence of Pro-Invasive Cancer-Associated Fibroblasts

A simple summary of how stromal cells regulate tumor formation is an active area of study. While cancer-associated fibroblasts have been shown to reduce or promote cancer transmission in a variety of settings, a systemic understanding of stromal involvement in determining cancer metastasis is lacking. Abstract: According to e. g. , pancreatic ductal cell carcinoma, pancreatic ductal cell carcinoma, and cancer-associated fibroblasts are now recognized as key regulators of cancer metastasis, particularly in cancers with high stromal content. Using published single-cell RNA sequencing results by Peng et al. , we performed a fibroblast-centric analysis of PDAC cancer as it transitioned from the primary site to a lymph node in the lymph node. We've characterized the evolution of fibroblast responses to cancer from a normal wound healing reaction in the early stages to the emergence of subclasses with myofibroblast and inflammatory fibroblasts, such as signatures. In particular mammals, we've previously proposed the term "evolved Levels of Invasibility," a framework that identifies stromal invasability as a selected phenotype, which explains the widespread and closely linked decrease in stromal invasion by placental trophoblasts and cancer cells. At successive stages of PDAC development, we discovered substantial differences in fibroblast subclasses, with the emergence of specific subclasses as cancer trespasses stroma to metastasize to proximal lymph nodes in PDAC samples. Genes describing this emergent fibroblast subclass of cancer genes from The Cancer Genome Atlas for PDAC cancers have been also linked to lymph node metastasis of cancer cells, according to a larger cohort of bulk RNAseq data from The Cancer Genome Atlas for PDAC cancers.

Source link: https://europepmc.org/article/MED/PMC9104173


Metastatic Transition of Pancreatic Ductal Cell Adenocarcinoma Is Accompanied by the Emergence of Pro-Invasive Cancer-Associated Fibroblasts.

Pancreatic ductal cell carcinoma, e. g. , pancreatic ductal cell carcinoma, and cancer-associated fibroblasts have been increasingly recognized as key regulators of cancer metastasis. Using published single-cell RNA sequencing results by Peng et al. , we conducted a fibroblast-centric analysis of PDAC cancer as it progressed from the primary site to the lymph node. We've characterized the change in fibroblast reaction to cancer from a normal wound healing reaction in the first stages to the emergence of subclasses with myofibroblast and inflammatory fibroblasts, including signatures. In certain mammals, we had previously proposed "Evolved Levels of Invasibility," a framework that describes the evolution of stromal invasibility as a specific phenotype. We observed substantial differences in fibroblast subclasses at subsequent stages of PDAC development, with the emergence of specific subclasses in cancer trespasses stroma to metastasize to proximal lymph nodes in PDAC samples. Genes describing this emerging fibroblast subclass also correlate with lymph node metastasis of cancer cells, according to a larger cohort of bulk RNAseq data from The Cancer Genome Atlas for PDAC cancers. Our results show that the complexities of stromal response to cancer is a result of stage-wise emergence of distinct fibroblast clusters, which are characterized by distinct gene sets, resulting in first a predominantly pro-resistive and then a pro-invasive type to the stroma.

Source link: https://europepmc.org/article/MED/35565326


Real-world safety and supportive care use of second-line 5-fluorouracil-based regimens among patients with metastatic pancreatic ductal adenocarcinoma.

AEs were seen during therapy, and the AEs were controlled by medication for those AEs in this review. Methods We conducted a retrospective observational review using the Flatiron Health database of adult patients with mPDAC who started second-line therapy between January 2016 and August 2020. Patients treated with FOLFIRINOX, FOLFOX, FOLFIRI, and liposomal irinotecan-based regimens were reported among 63. 6%, 34. 9%, 44. 9%, and 44. 9% of patients treated with FOLFIRINOX, 34. 9%, FOLFIRI, and 44. 9%, respectively, in 63. 6%, 34. 9%, 33. 9%, and 44. 9%, respectively, and 43. 9 percent In patients treated with FOLFIRINOX and FOLFIRI patients treated with FOLFIRI and FOLFIRI than in patients treated with liposomal irinotecan-based regimens, Atropine use was higher in patients treated with FOLFIRINOX and FOLFIRI than in patients treated with liposomal irinotecan-based regimens. Patients on FOLFIRI received the highest dose of pegfilgrastim to treat neutropenia.

Source link: https://europepmc.org/article/MED/35354375


Can Surgical Resection of Metastatic Lesions Be Beneficial to Pancreatic Ductal Adenocarcinoma Patients with Isolated Lung Metastasis?

Our study, conducted in 1342 patients in our institution, seeks to determine the effect of metastatectomy and prognostic factors in PDAC patients with isolated lung metastasis. Patients with isolated lung metastasis who underwent metastatectomy had improved survival when compared to patients who received only chemotherapy or supportive care. According to our findings, PDAC patients with isolated lung metastasis should be considered for multimodal therapy with chemotherapy and surgical therapy. After metastasis in PDAC patients with isolated lung metastasis, we investigated the impact of metastatectomy on survival. This retrospective review examined 1342 patients who were histologically diagnosed with PDAC with distant metastasis from January 2007 to December 2018, of which 83 patients had isolated pulmonary metastasis. Patients with isolated lung metastasis are referred to metastatectomy with primary pancreatic lesions.

Source link: https://europepmc.org/article/MED/PMC9099489


Can Surgical Resection of Metastatic Lesions Be Beneficial to Pancreatic Ductal Adenocarcinoma Patients with Isolated Lung Metastasis?

After metastasis in PDAC patients with isolated lung metastasis, we investigated the effects of metastatectomy on survival. This retrospective review examined 1342 patients who were histologically diagnosed with PDAC with distant metastasis from January 2007 to December 2018, of whom 83 patients had isolated pulmonary metastasis. Patients who underwent pulmonary metastatectomy were much higher in patients who underwent pulmonary metastatectomy than those who received only chemotherapy or supportive therapy. Metastatectomy with primary pancreatic lesions is recommended in PDAC patients with isolated lung metastasis.

Source link: https://europepmc.org/article/MED/35565195


Elderly Patients with Nondistant Metastatic Pancreatic Head Adenocarcinoma Cannot Benefit from More Radical Surgery.

Background The incidence of pancreatic cancer is on the rise globally, with pancreatic head cancer accounting for nearly 60%. Pancreatic head cancer is most common in people over the age of 60, and its morbidity and mortality increase with age. We examined whether these elderly patients with non-distant metastases would benefit more from expanded pancreaticoduodenectomy relative to standard pancreaticoduodenectomy. Methods 3317 elderly patients with pancreatic head cancer from the SEER database were included in the study based on the inclusion and exclusion criteria. The survival differences between the nonsurgical group and the surgical group were compared. There were also no significant differences in OS and CSS between the SPD and EPD groups after PSM. Conclusions This research uses PSM to determine the effects of EPD and SPD in elderly patients with nondistant pancreatic head adenocarcinoma.

Source link: https://europepmc.org/article/MED/35479664


The evolution of clinical outcomes in metastatic pancreatic adenocarcinoma: a 10-year experience at a tertiary referral center.

Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer mortality in the United States. We wanted to assess the mPDAC's clinical effects before and after incorporating these newer regimens into clinical practice. Methods An retrospective review of patients with mPDAC at our hospital between 2009 and 2018, who were followed up until December 2019 was published. The median OS and PFS for all patients with mPDAC were similar before and after incorporating newer treatment regimens into the clinical setting, according to the authors.

Source link: https://europepmc.org/article/MED/35400291

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions