Metastatic Melanoma Cells - DOAJ

Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis

Below, we showed for the first time that extracellular media acidification enhances spreading, migration, and invasion of patient-derived metastatic melanoma cells and up-regulates cell-surface expression of acid-sensitive channels including the ASIC1a, α-ENaC, and γ-ENaC subunits. To control metastatic melanoma development connected with the ASIC1a up-regulation, we recommended the ASIC1a prevention, -mambalgin-2 from Dendpoaspis polylepis venom. Using the mutant variant of mambalgin-2 with reduced activity towards ASIC1a, we validated that the primary molecular target of mambalgin-2 in melanoma cells is the ASIC1a subunit. Therefore, targeting ASIC1a by medicines such as mambalgin-2 can be an appealing technique for metastatic melanoma treatment.

Source link: https://doi.org/10.3390/biomedicines9101324

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