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Metastatic Malignant Melanoma - Europe PMC

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Last Updated: 02 February 2022

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Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma.

Regardless of the intrinsic BRAF/NRAS mutation status, we show the hexameric TRAIL-receptor-agonist IZI1551 in MM cells to effectively induce apoptosis in MM cells. Conditioning of the EC 50 dose of IZI converted the phenotype of IZI-sensitive parental MM cells into a rapid proliferating and invasive IZI-resistant metastasis. We found focal adhesion kinase to play a dual role in phenotype switching, according to Mechanistically. In the cytosol, stimulated FAK stimulates survival pathways in a PI3K- and MAPK-dependent manner. The FERM domain of FAK, which is not represented in the majority of MM, and therefore intrinsic apoptosis, is blocked in the nucleus. Both FAK's as well as FAK's demise, as well as FAK's crash, and pharmacological inhibition, respectively, reversed the metastatic phenotype-switch and restored IZI responsiveness and reverted izai responsiveness. Regardless of the intrinsic BRAF/NRAS mutation status, FAK inhibition may have reduced the MM cells isolated from patient metastasis that had relapsed from targeted kinase inhibition to cell death.

Source link: https://europepmc.org/article/MED/35022419


Identification of Potential Core Genes Between Primary and Metastatic Malignant Melanoma and Analysis of Their Immune Correlation.

Objectivists (electronox) melanoma, screen out immune-related genes in main genes, and analyze their immune correlation, so looking for early diagnostic biomarkers of cutaneous malignant melanoma and metastasis is among the goals. In addition, the online Gene Expression Profiling Interactive Analysis software was used to analyze the prognostic value of hub genes present in metastatic melanoma patients. Among them, the patients with overexpression of PKP1 had shorter lives. In addition, two immune-related genes in hub genes were tested out, and both of them were related to anti-tumor immunity, but their expression level did not influence CMM patients's overall survival.

Source link: https://europepmc.org/article/MED/35046701


Amelanotic metastatic gastric malignant melanoma: a case report.

Melanoma, a malignant form of cutaneous cancer with an increasing prevalence since the 1970s, accounts for over 75% of all deaths related to skin cancer, particularly in western countries. However, the overwhelming prevalence of gastrointestinal metastasis of malignant melanoma is often misdiagnosed due to a lack of concrete clinical signs, especially in the rare cases of amelanotic skin, accounting for around 2% of all metastatic cases. In conclusion, amelanotic neoplasm observed during gastroscopy in patients with melanoma history should be confirmed by pathological examination, exposing the possibility of melanoma metastasis and establishing evidence for the following therapy.

Source link: https://europepmc.org/article/MED/34459456

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions