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Metastatic Malignant Melanoma - DOAJ

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Last Updated: 02 February 2022

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Fulminant metastatic malignant melanoma

For the past month, a 50-year-old lady has been plagued with chest pain and cough for the past month. Tumor cells in the lymph node were found to be brownish-black pigment laden tumour cells, according to Fine needle aspiration cytology from the lymph node. The patient was found to have full-blown metastatic malignant melanoma of left foot with metastasis to cervical lymph nodes and pleura. This case study re-emphasizes the importance of a multi-step strategy to determine diagnosis early.

Source link: https://doaj.org/article/22da3eae13b645168838051def2887d7


Identification of Potential Core Genes Between Primary and Metastatic Malignant Melanoma and Analysis of Their Immune Correlation

Methods and Methods: We analyzed two microarray datasets derived from the Gene Expression Omnibus database to determine the potential differences between primary and metastatic melanoma, screen out immune-related genes in core genes, and analyze immune correlation, thus looking for the first diagnostic biomarkers of cutaneous malignant melanoma and metastasis. In addition, the online Gene Expression Profiling Interactive Analysis software was used to determine the prognostic value of hub genes expressed in metastatic melanoma patients.

Source link: https://doaj.org/article/3b824839f6474d709ba0f4b813eaa504


BRAF Mutation Status in Primary, Recurrent, and Metastatic Malignant Melanoma and Its Relation to Histopathological Parameters

BRAF mutations are a typical finding in malignant melanoma. Object: To determine BRAF mutation status in primary, recurrent, or metastatic MM, as well as its relationships with histopathological studies, please refer to histopathological results. Methods: We analyzed 203 samples from 178 consecutive patients, including 129 primary cutaneous MM, 49 metastatic and recurrent MM of unknown primary site, and 25 cases of primary MM recurrences or metastases of primary MM. BRAF mutations in exon 15 were discovered with real-time polymerase chain reaction, exon 15 or direct sequencing or pyrosequencing. We discovered a 42. 1% prevalence of BRAF mutations at codon 600 among our patients, with 84% of whom had the V600E mutation. The only significant predictors of BRAF mutation were identified as type and ulceration, according to a logistic regression study. BRAF in superficial spreading and nodular forms were found, as well as in acral lentiginous and lentigo maligna forms. Intermediate frequencies were recorded in situ MM and primary dermal melanoma.

Source link: https://doi.org/10.5826/dpc.0901a13

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions