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Metastatic Brain Tumors - Springer Nature

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Last Updated: 27 January 2022

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Diagnostic, grading and prognostic role of a restricted miRNAs signature in primary and metastatic brain tumours. Discussion on their therapeutic perspectives

Brain tumours remain one of the "hard-to-treat" disease groups with no improvement in patients' survival. The main aim of the current study was to find an accurate and cost-effective brain tumour detection and grading system. Patients in Bulgaria obtained fresh tumour tissue from their patients, including high-grade gliomas, low-grade gliomas, and lung metastases from lung cancer. In high-grade gliomas, low-grade gliomas, and brain metastases in comparison to normal brain tissue, we selected a signature of miR-21, miR-10b, miR-7, miR-491 that had good diagnostic capability in miR-21, miR-10b, miR-7, miR-491 that metastases in high-grade gliomas, low-grade gliomas, and brain metastases. MiR-10b could reliably distinguish brain metastases from high-grade gliomas, according to our findings, while MiR-491 could distinguish low-grade gliomas and brain metastases from low-grade gliomas. MiRNA signature information is also reviewed, including ongoing research on miRs-based targeted therapy relating to our chosen miRNA signature.

Source link: https://doi.org/10.1007/s00438-021-01851-5


The epidemiology of primary and metastatic brain tumors in infancy through childhood

According to the WHO CNS 4th and 5th editions classifications, the aim of this study is to investigate the epidemiology of primary and metastatic pediatric brain tumors in the United States. Methods Pediatric patients with a brain tumor diagnosed between 2004 and 2017 were identified in the National Cancer Database and categorized by NICHD age groups. Patients were identified with 23,978 pediatric brain tumor patients. A minority of brain tumors were of ependymal, glioneuronal & neuronal, germ cell tumor, mesenchymal non-meningothelial, cranial nerve, choroid plexus, meningioma, pineal, and hematolymphoid varieties. In patients of Asian/Pacific Islander race/ethnicity, GCTs were more common in patients of Asian/Pacific Islander race/ethnicity. Brain metastases were extremely uncommon, accounting for 1. 4% overall, with the most common primary tumor being neuroblastoma and non-CNS sarcoma. Conclusion We systematically discussed pediatric brain tumor epidemiology in the context of a new classification system, thereby validating our current knowledge and providing key insights.

Source link: https://doi.org/10.1007/s11060-021-03927-z


Comparative associations of baseline frailty status and age with postoperative mortality and duration of hospital stay following metastatic brain tumor resection

Metastatic brain tumors are the most common intracranial neoplasms in the United States. Although baseline frailty status has been established as a reliable predictor of morbidity and mortality in a variety of surgical specialties, reports regarding cranial neurosurgical oncology are limited. During the time of 2015-2018, adult metastatic brain tumor patients treated with resection were identified in the National Inpatient Sample. Among the 13,650 metastatic brain tumor patients diagnosed, 28. 8% were robust, 31. 2% were frail, and 15. 8% were extremely frail. Both mortality and elos were found to be discrimination of frailty in comparison with age for both mortality and elos, according to a ROC curve review. Following metastatic brain tumor resection, Frailty may be a more accurate predictor of postoperative outcomes in comparison to age.

Source link: https://doi.org/10.1007/s10585-021-10138-3

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions