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Evidence to support the use of intraoperative radiotherapy in brain tumors that necessive surgical intervention continues to accumulate as with the rise and eventual acceptance of cranial stereotactic radiosurgery in a period dominated by traditional radiotherapy. Although the clinical trial protocols in treating glioblastoma with IORT call for a boost of cavitary radiation ahead of the planned definitive adjuvant radiation dose escalation to the maximum level achievable with IORT, a logical response can be obtained with IORT in metastatic disease, reducing the need for additional episodes of care while still providing local control equal or superior to that obtained with SRS in a single fraction. In this review, we explore the latest clinical findings on IORT in the treatment of brain tumors, as well as a discussion of the unique dosimetric and radiobiological factors inherent in IORT that might account for improved outcome results that have not been seen in other methods.
Source link: https://doi.org/10.3389/fonc.2021.768168
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