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The most common cause of CRC-related mortality is liver metastasis, and is largely caused by interactions between CRC cells and the tumor microenvironment in the liver. In turn, promoting CRLM, highly metastatic CRC cells produced more miR-181a 5p-rich EVs than cells that have a low metastatic potential, according to the present study. Clinically, high serum EV with miR-181a5p was positively correlated with liver metastasis in CRC patients. Taken together, highly metastatic CRC cells-derived EVs with a high in miR-181a–5p may stimulate HSCs and re-form the TME, thus aiding liver metastasis in CRC patients.
Lung cancer is the most common cause of cancer-related deaths in patients with distant metastasis, with 5-year survival rates of about 7% in patients with five-year survival rates. Although targeted therapy has improved the clinical outcome of nonsmall cell lung cancer patients, nonsmall cell lung cancer survivors have been reduced, drug resistance remains a significant obstacle. Exosomes from tumor cells to neighbor cells or cells at distant sites of the body stimulate tumor microenvironment and promote tumor metastasis. Exosomal miRNAs are also used as noninvasive biomarkers for early diagnosis of lung cancer.
Source link: https://onlinelibrary.wiley.com/doi/10.1002/mc.23378
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