Metastasis Suppressor gene - Crossref

The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53

We've found that interacting with the 5′ upstream region activates the KAI1 gene in a specific manner. The p53 response region is found at 860 bases upstream of the transcriptional initiation site, and it includes a typical tandem repeat of the p53 consensus binding sequence. In addition, immunohistochemical analysis of 177 samples of human prostate tumors revealed that the expression of the KAI1 gene was closely related to that of the p53 gene, and that patients' poor survivals were largely affected by the absence of these two genes. Our results reveal a direct correlation between p53 and KAI1 genes, indicating that the absence of p53 function, which is common in several types of cancer, leads to the down-regulation of the KAI1 gene, which may result in metastasis.

Source link: https://doi.org/10.1073/pnas.95.19.11307

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