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Metastasis Microenvironment - Wiley Online Library

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Last Updated: 09 May 2022

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Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation

Abstract Breast cancer is the most common cancer among women, and metastases in distant organs are the most common cause of cancer-related deaths. Although the survival of early stage breast cancer patients has increased dramatically, the 5year survival rate of metastatic patients has barely increased in the last 20 years. The importance of FFL of cancer cells with their microenvironment includes the investigation of the mystery, genetic differentiation, vitamins/metabolites, and the fact that novel therapies should not only attack the tumor microenvironment, but also the tumor microenvironment, which are thick as thieves.

Source link: https://onlinelibrary.wiley.com/doi/10.15252/emmm.202114283


Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis

Emerging research has concentrated on targeting the adverse physiological causes of the TME to attenuate disease rather than specifically targeting tumor cells, which has been a potential therapeutic approach. In vitro construction of the tumor microenvironment, applications, and clinical relevance in the TME, we explored the sources and roles of mechanical factors in the TME, cell sensing, mechano-biological coupling, and signal transduction.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/cac2.12294


Engineer a pre‐metastatic niched microenvironment to attract breast cancer cells by utilizing a 3D printed polycaprolactone/nano‐hydroxyapatite osteogenic scaffold – An in vitro model system for proof of concept

Breast cancer bone metastasis is not a random process, as shown by the color diagram. Human mesenchymal stem cells were seeded into PCL scaffolds for osteogenic differentiation, establishing the pre-metastatic niched microenvironment. Also, MDAMB231, MCF-7, and MDA-MB-453 breast cancer cells were recruited to the osseous PCL scaffolds by osseous PCL scaffolds, according to the osseous PCLnHA scaffolds. Our results revealed that the mRNA levels of alkaline phosphatase, runt-related transcription factor 2, and osteocalcin of hMSCs on the PCL scaffolds were dramatically elevated compared to those on the PCL scaffolds on day 7, 14, 28, 28. This early research found that a planned tissue engineering scaffold could be used to create a bone-mimicking environment that serves as a novel platform to recapitulate the pre-metastatic niche and support bone metastasis by breast cancer.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35021


Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment

The most common cause of CRC-related death is liver metastasis of colorectal cancer, and it is mainly attributed to liver microenvironment interactions. In turn, promoting CRLM, the present study showed that highly metastatic CRC cells released more miR-181a/5prich EVs than cells that have a low metastatic potential. Patients with liver metastasis in CRC patients who had high serum EV containing miR-181a5p were positively correlated with liver metastasis. MiR-181a5p-derived EVs with a high degree of miR-181a5p could stimulate HSCs and remodel the TME, thus encouraging liver metastasis in CRC patients.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jev2.12186


18F‐fluorodeoxyglucose uptake in PET is associated with the tumor microenvironment in metastatic lymph nodes and prognosis in N2 lung adenocarcinoma

In lung adenocarcinoma, this research sought to clarify the connection between fluorodeoxyglucose accumulation and the microenvironment in metastatic LNs. We retrospectively evaluated 62 patients with surgically resected pathological N2 lung carcinoma adenocarcinoma who underwent preoperative PET. The overall performance in the LN SUVmax high group was noticeably lower than in the low group. Metastatic cancer cell proliferation in extranodal tissue in LN's high-risk cohort was more prevalent, with the number of CD204+ TAMs and SMA+ CAFs in metastatic LNs significantly higher than in the low group. Cancer cells coexisting with CAFs were more invasive than those without CAFs, according to Hybrid spheroid models. Patients with N2 lung adenocarcinoma showed a strong correlation between LN SUVmax and poor prognosis in patients with poor prognosis. In addition, LN SUVmax was shown to be linked to the presence of tumor-promoting stromal cells in metastatic LNs.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/cas.15266

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions