Advanced searches left 3/3

Metastasis Microenvironment - Europe PMC

Summarized by Plex Scholar
Last Updated: 09 May 2022

* If you want to update the article please login/register

Bone-targeted nanoplatform enables efficient modulation of bone tumor microenvironment for prostate cancer bone metastasis treatment.

As there is currently no approved treatment for patients of prostate cancer bone metastasis, it was difficult to determine the appropriate treatment techniques. The relationship between cancer cells and bone microenvironment, as well as the Sonic hedgehog protein signaling in the bone microenvironment, is extremely important in prostate cancer bone metastasis. The SHH encourages osteoblast maturation and osteoblast maturation, with osteoblast formation and osteoblast transformation, but RANKL is then obscured to induce osteoclastogenesis, which leads to osteoclastogenesis. This research results in the production of bone-targeting calcium phosphate lipid hybrid nanoparticles coated with docetaxel and SHH siRNA for PCa bone metastasis treatment.

Source link: https://europepmc.org/article/MED/35285760


Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis.

The development, proliferation, invasion, and metastasis of solid tumors is fueled by a dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment. Emerging research has focused on the adverse mechanical causes of the TME to attenuate disease rather than conventionally attacking tumor cells themselves, which has been a potential therapeutic strategy.

Source link: https://europepmc.org/article/MED/35470988


Tumor microenvironment-regulated nanoplatforms for the inhibition of tumor growth and metastasis in chemo-immunotherapy.

Chemotherapy is one of the most common medical anticancer drugs. Notably, the combination of MM NPs, doxorubicin hydrochloride, and immune checkpoint inhibitors improved the synergistic efficiency of chemo-immunotherapy in a bilateral animal model, which also reduced primary tumor formation and distant untreated tumors. These results showed that MM NPs with TME regulatory functions could potentially increase the effectiveness of chemo-immunotherapy.

Source link: https://europepmc.org/article/MED/35439801


Dynamic observation: Immune-privileged microenvironment limited the effectiveness of immunotherapy in an intraocular metastasis mouse model.

Methods We established a new mouse model of intraocular metastasis by intracarotid injection of cutaneous melanoma cells. All mice had IM in the left eye, but the right eye was healthy, while the right eye had no problems. Introcular metastasis began intraocular growth at an early age, and intraocular metastasis development resulted in a variety of secondary abnormalities, including corneal swelling, retinal detachment, and intratumoral haemorrhage. PD-L1low corneal tissue resisted tumor proliferation with high numbers of CD8+ T cells infiltration, whereas CD8+ T cells were ineffective in PD-L1high uveal metastasis, with a high incidence of PD-L1high corneal tissue. Although these CD8+ T cells in the IM were not exhausted or had a higher rate of cytotoxicity than CD8+ T cells in the blood, FasL+ ocular tissue can significantly reduce these IM infiltrating T cells. Enhancing the visual ability of tumor-infiltrating CD8+ T cells may be one of the easiest ways to raise the visual ability.

Source link: https://europepmc.org/article/MED/35398850


Bladder cancer-derived exosomal KRT6B promotes invasion and metastasis by inducing EMT and regulating the immune microenvironment

However, bladder cancer's exact role and mechanism of exosome-encapsulated nucleic acids and proteins is uncertain. This study was designed to determine the effect of tumor-derived exosomes on bladder cancer formation and formation. Methods: In this research, the gene expression profiles and clinical details of two independent Gene Expression Omnibus databases were collected from the Cancer Genome Atlas database and two independent Gene Expression Omnibus datasets. Only the presence of KRT6B in the top ten upregulated and top ten down-regulated exosomal genes had a statistically significant effect on bladder cancer patients, according to a survival study based on the ULCAN database. In addition, a clinical correlation review revealed that an elevated level of KRT6B was highly associated with bladder cancer stages, grades, and metastasis status. KRT6B was not only involved in the epithelial-mesenchymal transition pathways linked to epithelial-mesenchymal transition pathways, but also the immune response in bladder cancer, according to the GSEA report.

Source link: https://europepmc.org/article/PPR/PPR477607


Integrated Analysis of Genes Associated With Immune Microenvironment and Distant Metastasis in Uveal Melanoma.

The aim of this research was to identify genes associated with inflammation microenvironment and clinical characteristics for survival prediction of uveal melanoma patients. The cancer Genome Atlas and Gene Expression Omnibus databases contain UVM's datasets and clinical data. We divided the UVM patients into low and high immune cell infiltration groups, defined differentially expressed genes, established a weighted gene co-expression network, and established a prognostic prediction network and nomogram for UVM. Our review revealed that DEGs were enriched in cytokine signaling in the immune system, improved immune response control, and adaptive immune system. A total of fifteen candidate genes were extracted from DEGs and genes that were positively related to tumor metastasis.

Source link: https://europepmc.org/article/MED/35433689


Tumor Microenvironment Shapes Colorectal Cancer Progression, Metastasis, and Treatment Responses.

Colorectal cancer is one of the most common disorders worldwide, accounting for hundreds of deaths. The importance of these non-cell-autonomous signaling pathways is being discussed as the role of the tumor microenvironment in CRC progression and metastasis is gradually revealed. In this report, we summarize the latest knowledge of the TME in CRC progression and metastasis by focusing on the gut microbiota and host cellular and non-cellular components.

Source link: https://europepmc.org/article/MED/35402443


Gut Microbiota Alteration Influences Colorectal Cancer Metastasis to the Liver by Remodeling the Liver Immune Microenvironment.

Methods The gut microbiota and its potential role in CRC liver metastasis were shown in vivo and in vitro studies. B. vulgatus serum levels were positively correlated with KC values, which were highly correlated with KC values. In the P. mirabilis group, the number of liver metastatic nodules was elevated in the P. mirabilis group and decreased in the B. vulgatus group. The number of KCs in P. mirabilis' group decreased and increased in the B. vulgatus group, but not so much in the B. vulgatus group. In vitro, as P. mirabilis or B. vulgatus doses increased, there was an opposite effect on KC proliferation in dose- and time-dependent manners. P. mirabilis stimulated CT26 cell migration by reducing KC proliferation, triggering KC proliferation, but B. vulgatus stopped this migration. Conclusions: The liver's increased supply of P. mirabilis and reduced amount of B. vulgatus play significant roles in CRC liver metastasis, which may be due to KC reductions.

Source link: https://europepmc.org/article/MED/35318288


Pyroptosis-Related lncRNAs for Predicting the Prognosis and Identifying Immune Microenvironment Infiltration in Breast Cancer Lung Metastasis.

Breast cancer is the second leading cause of death among women and is extremely heterogeneous. Patients with BC from the Cancer Genome Atlas Database cohorts were found with 20 PR-related regulators, showing a strong correlation between BC prognosis and PR. Lung metastasis is a common disease in the early stages of BC, contributing to a poor quality of life. Using LASSO-Cox analysis of PR-related and BC lung metastasis, eight differentially expressed lncRNAs were discovered. Our findings lay the groundwork for future research into PR and confirm that RS could predict patient prognosis with BC.

Source link: https://europepmc.org/article/MED/35309942


Hypoxic Microenvironment-Induced Reduction in PTEN-L Secretion Promotes Non-Small Cell Lung Cancer Metastasis through PI3K/AKT Pathway.

Objective Lung cancer is the most common cause of cancer-related deaths around the world. The aim of this research was to investigate the effects of hypoxic microenvironment on PTEN-L secretion and the effects of PTEN-L secretion and PTEN-L, as well as the effects of PTEN-L on lung cancer metastasis and the potential mechanisms. The transfection of PTEN-L overexpression constructor, or HIF-1 -siRNAs, was carried out to alter PTEN-L or HIF-1's expression. To simulate hypoxia, 200 M CoCl2 medium was used for 72 hours under 37°C for 72 hours to simulate hypoxia. The cell proliferation and apoptosis of the A549 cells were determined by the Cell Counting Kit-8 assay and Annexin V-FITC/PI-stained flow cytometry assay, respectively, assay, respectively. PTEN and PTEN-L are downregulated in lung cancer tissues and cells, as shown by the following: PTEN and PTEN-L have been downregulated in lung cancer tissues and cells. PTEN-L's protein expression in lung cancer cell lines' culture medium has been reduced.

Source link: https://europepmc.org/article/MED/35280516

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions